全球大规模的抗生素耐药性决定因素的分子流行病学在Streptococcus pneumoniae中
Kazi Shefaul Mulk Shawrob1, Achal Dhariwal1, Gabriela Salvadori1,2
1Institute of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Microbial genomics
|July 2, 2025
概括
肺炎链球菌中的抗菌素耐药性是全球性的威胁. 公开的全基因组测序数据显示,多药耐药性正在增加,特别是在宏化物耐药性基因和特定血清型中,需要更新监测和控制策略.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 流行病学 流行病学
背景情况:
- 肺炎链球菌 (Streptococcus pneumoniae) 是全球与抗菌素耐药性相关的主要死亡原因.
- 监测抗生素耐药性决定因素对于有效监测S. pneumoniae至关重要.
研究的目的:
- 通过使用公开的全基因组测序数据,调查S. pneumoniae中抗生素耐药性决定因素的存在和分布.
- 专注于多药耐药性 (MDR) 模式及其与全球血清型分布的相关性.
主要方法:
- 利用NCBI病原体检测数据库中的75,161个公开可用的全基因组序列.
- 采用AMRFinderPlus用于抵抗模式识别和用于血清定型的in silico工具.
- 分析了14种抗生素类别的基因/等位基因计数,以评估耐药性趋势.
主要成果:
- 在16.7%的分离物体中发现了多药性耐药性 (MDR),亚洲和南美洲的比例正在上升.
- 宏类耐药基因,特别是 mef (A) /msr (D),显示出显著的增加.
- 血清型19F,23F,15A,6B和19A的MDR率很高;33F,22F,10A和23A的血清型显示出抗性显著增加. 血清型13呈现出高且不断增加的MDR率.
结论:
- 公共可用的全基因组测序数据对于追踪S. pneumoniae的抗生素耐药性是有价值的.
- 耐药性决定因素的显著全球和血清型特定变化凸显了对适应性监测和控制策略的需求.
- 这些发现有助于评估治疗和疫苗接种策略,以控制抗菌素耐药性.
相关概念视频
Development of Antibiotic Resistance
220
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
220
Modern Molecular Taxonomy
157
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
157
Antibiotic Selection
55.4K
Overview
55.4K
Global Regulatory Systems
82
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
82
Gene Regulation in Microbial Communities: Quorum Sensing
97
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
97
Genomic DNA in Prokaryotes
44.7K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
Genomic Diversity in Bacteria
Although bacterial genomes are much...
44.7K


