液晶结构的相极限和界面特征对表面活性剂-肌肤活性剂组成的依赖性
Sakshi Sharma1, Kamal Kant Kaushik1, Karan Bisht1
1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) - Raebareli, Lucknow 226002, India.
Langmuir : the ACS journal of surfaces and colloids
|July 2, 2025
概括
表面活性剂和表面活性剂的比率显著影响微乳液中的液晶结构. 优化这种比率,特别是用TPGS-Span 80在1:3的比率,可以为长期存储配方产生强大的粘弹性状液晶.
科学领域:
- 物理化学 物理化学
- 材料科学 材料科学 材料科学
- 合体和表面化学
背景情况:
- 无离子微乳液是多功能系统,在药物输送中具有潜在的应用.
- 控制微乳液自组装成液晶 (LC) 阶段对于开发先进配方至关重要.
- 表面活性剂-表面活性剂 (S混合物) 比率是影响微乳液阶段行为和结构的关键参数.
研究的目的:
- 研究表面活性剂-表面活性剂 (TPGS-Span 80) 比率对非离子微乳液系统中液晶结构的形成和特征的影响.
- 了解不同的S混合比如何影响相位过渡,结构性质和学行为.
- 确定最佳的S混合组合,以开发稳定且功能化的粘弹性LC矩阵.
主要方法:
- 使用TPGS-Span 80在1:1,1:3和3:1的比率,以油酸作为油阶段构建伪第三阶段图.
- 使用偏光显微镜进行表征,以观察相位过渡 (异向异向).
- 微角X射线散射 (SAXS) 用于确定叶片结构和层间距离.
- 风湿学测量 (振荡测试) 以评估粘弹性和牛顿式/非牛顿式行为.
主要成果:
- S混合比率显著影响了单相区域,TS 1:1 > TS 3:1 > TS 1:3.
- 极化光显微镜证实,在添加水后,异热到异热的相变,表明LC的形成.
- 萨克斯数据揭示了微乳液的转化为状液晶,其特点是波向量转移比率为1:2:3的峰值.
- TS 1:3 组合导致了更深层次的斑块胀和粘度增加.
- 液晶结构表现出非牛顿和粘弹性行为,与微乳液的牛顿行为形成鲜明对比.
- 该TS 1:3组合产生了机械坚固和灵活的板块.
结论:
- 表面活性剂-表面活性剂比率是调整非离子微乳液相位行为和液晶结构的关键因素.
- TS 1:3比率是形成稳定,粘弹性状液晶结构的最佳选择,具有理想的机械性能.
- 这些发现强调了优化表面活性剂混合物的潜力,用于开发使用粘弹性LC矩阵的长期存储配方.
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