黑色素调节和自调节由Rosa centifolia L.提取物及其关键化合物 (阿斯特拉加林和酸)

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Huaqian Mei¹, Qilin Li², Haodong Li²

¹Shangdong Huawutang Biotechnology Co., Ltd, Jinan, China.

Chemistry & biodiversity

|July 2, 2025

概括

罗莎百叶草提取物通过抑制黑色素的产生和铁酶的活性,有效地使皮肤变白. 埃拉基酸和阿斯特拉加林等关键化合物通过各种分子途径显示出显著的皮肤美白潜力.

科学领域:

化品科学化品科学
皮肤病学皮肤病学
自然产品化学自然产品化学

背景情况:

罗莎百叶花以抗氧化和抗炎作用而闻名.
有限的研究存在于它的皮肤美白能力.

研究的目的:

在体外研究Rosa centifolia的皮肤美白特性.
确定活性化合物及其作用机制.

主要方法:

粉红百叶草 (RCFE) 的闪光提取和黄类素和类素的量化.
建立了HPLC/DAD方法,用于分析基酸 (ECA),素 (ASG) 和异基.
用于通过ELISA和Western Blot评估RCFE,ECA和ASG的抗黑色素效应的B16细胞模型.

主要成果:

埃拉基酸 (3.00 微克/毫升) 和阿斯特拉加林 (6.00 微克/毫升) 显著抑制了黑色素发生和铁酶活性.
RCFE,ASG和ECA抑制了黑色素发生,铁酶活性和MITF表达.
这些化合物影响了TRP1和TRP2的表达,并增强了细胞自,由LC3-II/LC3-I比率和Beclin-1的增加和p62.2的减少表明.

结论:

粉红百叶草提取物及其活性化合物 (ECA,ASG) 具有显著的皮肤美白潜力.
该机制涉及抑制黑色素生成,铁酶活性和MITF,同时促进自.
为开发用于护肤和药品的R. centifolia衍生成分提供了基础.

关键词:

罗莎百叶花 (Rosa centifolia) 是一个百叶花.自自是自的过程.生物活动是生物活动.黑色素的产生是黑色素的产生.蛋白质表达蛋白质表达

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