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改善孕产妇和产周健康结果的孕产妇肠道微生物干预措施:目标产品配置专家共识和管道分析分析
Kate Mills1, Joelle Tan2, Tahlia Guneratne1
1Maternal, Child and Adolescent Health Program, Burnet Institute, Melbourne, Australia.
PloS one
|July 2, 2025
概括
这项研究开发了一种针对母体肠道益生菌的目标产品概况 (TPP),并确定了有前途的候选者. 很少有益生菌进入后期研究阶段,强调需要进行疗效试验.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 孕产妇健康 孕产妇健康
背景情况:
- 母亲的肠道微生物组在怀孕结果和婴儿健康方面发挥着至关重要的作用.
- 针对母体肠道微生物组的干预措施正在出现,但缺乏标准化的开发标准.
- 需要定义的目标产品配置文件 (TPP),以指导有效益生菌的研发.
研究的目的:
- 建立一种针对母体肠道微生物组的益生菌的新型TPP.
- 为孕产妇微生物干预构建一个研发管道.
- 确定符合TPP标准的高潜力益生菌候选者.
主要方法:
- 一种混合方法的方法,涉及到利益相关者采访,国际调查和公众咨询.
- 系统的研发管道开发和数据库搜索 (阿迪斯洞察,临床试验.gov等). ) 的情况.
- 对利益相关者的反进行分析,以完善TPP,并根据定义的标准匹配益生菌候选者.
主要成果:
- 在大多数TPP变量 (16个最低,14个最佳目标) 上达成共识.
- 在母体微生物组管道 (2000-2023) 中发现了8种益生菌候选者.
- 一个高潜力 (Vivomixx) 和两个中等潜力 (Lactobacillus spp., Bifidobacterium spp.) 确定了一些益生菌候选者.
结论:
- 这项研究提出了第一个TPP和管道分析对母体肠道微生物干预措施.
- 鉴定了具有更高潜力的益生菌候选者,尽管很少有人达到了后期发展阶段.
- 进一步的疗效试验对于推进孕产妇益生菌干预措施至关重要.
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