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优化策略,以减轻达拉图穆马布在血液银行测试中的干扰:减少成本和时间

Tom Yu¹, Antonio Insigne², Walia Anushka¹

¹University of California San Francisco, San Francisco, CA, United States.

American journal of clinical pathology

|July 2, 2025

概括

接受达拉图姆 (DARA) 输血的多发性骨髓瘤患者没有增加红细胞与免疫接种风险. 一个新的,具有成本效益的输血前检测策略有效地减轻了DARA干扰.

科学领域:

血液学血液学血液学
输血医学输血医学
在瘤学瘤学.

背景情况:

多发性骨髓瘤 (MM) 患者的达拉图马布 (DARA) 治疗可能会干扰输血前红细胞 (RBC) 检测.
目前的指导方针建议在DARA之前进行红细胞表型化/基因型化,但缺乏标准化,具有成本效益的输血前检测协议.
之前的研究报告了低RBC免疫风险和缓解策略,但没有提出具有成本效益的解决方案.

研究的目的:

为了评估与DARA治疗的MM患者的红细胞配免疫风险.
提出一个成本效益高的算法,用于DARA治疗患者的输血前检测.

主要方法:

在9.4年内接受DARA和RBC输血的850名MM患者的回顾性分析.
收集的人口统计数据,血清学资料 (血液类型,ABScreen,ABScreenID),RBC表型/基因型和交叉匹配数据.
与对照组相比,DARA前后临床显著抗体形成的发生率 (P < .05).

主要成果:

在DARA治疗的850名MM患者中,有172人 (20%) 接受了红细胞输血.
所有患者在DARA后都表现出泛聚丁;没有形成新的临床显著的alloantibodies.
一个优化的输血前策略显著减少了周转时间和成本.

结论:

这项广泛的研究表明,在接受DARA治疗,输血MM患者中,红细胞配免疫风险没有增加.
一种新的输血前检测策略有效地减轻了与DARA相关的输血干扰.
拟议的策略为这种患者群体的输血前检测提供了一个具有成本效益的解决方案.

关键词:

红细胞合免疫接种.经济效益性经济效益性在达拉图穆巴马布.在输血前进行干扰测试.

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