从总度到生物可访问负载:通过概率性暴露方法和毒动力学建模,重新评估土壤重金属的风险
Shiyi Yi1, Xiaonuo Li2, Weiping Chen1
1State Key Laboratory for Ecological Security of Regions and Cities, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; College of Resource and Environment, University of Chinese Academy of Sciences, Beijing 100049, China.
在健康风险评估 (HRA) 中考虑生物可访问性可以显著降低重金属 (HM) 过度估计的风险. 这种方法为更好的土壤环境管理提供了更准确的暴露估计.
科学领域:
- 环境毒理学环境毒理学
- 风险评估 风险评估
- 地质化学 地质化学
背景情况:
- 传统的健康风险评估 (HRA) 往往高估了风险,因为它没有考虑重金属的生物可访问性.
- 工业区的土壤污染给环境和健康带来了重大挑战.
- 生物可访问性是影响环境污染物对健康的实际风险的关键因素.
研究的目的:
- 调查生物可访问性对重金属 (HM) 在工业区的健康风险评估的影响.
- 将体外生物可访问性数据整合到概率HRA和生理学基础毒动力学 (PBTK) 模型中.
- 在考虑生物可访问性时评估HRA的准确性和可靠性.
主要方法:
- 在一个工业聚合区的126个土壤样本中对HMs进行系统的表征.
- 在体外测试以确定生物可访问的HM度.
- 可能的HRA和基于生理的毒动力学 (PBTK) 建模,包括生物可访问性数据.
主要成果:
- 考虑到生物可访问性减少了非致癌风险的高估,高达82.83%的成人和78.93%的儿童.
- 当包括生物可访问性时,致癌风险的过高估计减少了大约70%.
- 基于生理学上的毒动力学 (PBTK) 模型预测显示,尿液中HM度大幅降低 (Cd为60.41%,Cr为98.50%).
- 纳入生物可访问性导致金属和年龄组的验证值偏差更加稳定和准确.
结论:
- 将生物可访问性纳入HRA提供了更准确和可靠的HM暴露估计.
- 这种方法有效地避免了对相关健康风险的高估.
- 考虑生物可访问性有助于在土壤环境健康管理方面做出更明智的决策.
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