人体便中的微塑料与结直肠癌风险之间的关联
Jingyan Xu1, Jianli Qu2, Hangbiao Jin3
1Department of Pharmacy, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang 324000, PR China.
Journal of hazardous materials
|July 2, 2025
概括
在中国的一项研究中,便中微塑料 (MP) 含量较高与结直肠癌 (CRC) 风险增加有关. 这项研究强调了塑料污染和人类疾病的潜在环境健康问题.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 微塑料 (MP) 是无处不在的环境污染物,存在于水,空气和食物中.
- 越来越多的证据表明,MPs可以破坏胃肠道功能.
- 人类微塑料暴露与结直肠癌 (CRC) 风险之间的关联尚未得到充分理解.
研究的目的:
- 在中国人口中调查便中微塑料度与结直肠癌风险之间的关系.
- 探索潜在的剂量反应关系,并确定具有更高风险的子组.
主要方法:
- 一项涉及258名CRC患者和493名健康对照者的病例控制研究.
- 使用激光红外成像光谱仪量化便中的微塑料度.
- 统计分析包括多变量逻辑回归和受限立方线分析.
主要成果:
- 在CRC病例中,便中MP度的中位数明显高于对照组 (43个物品/g干重量) (62个物品/g干重量).
- 与最低四分位数相比,MP暴露四分位数最高的个体患CRC的几率增加了11.3倍.
- 观察到一种非线性剂量反应关系,女性和经常食用辛或高脂肪食物的女性更强烈.
结论:
- 这项研究提供了第一个流行病学证据,表明微塑料暴露量增加和结直肠癌风险增加之间存在潜在联系.
- 研究结果表明,微塑料污染可能会对环境健康构成重大风险.
- 需要进一步的研究来阐明机制,并确认这些协会在不同的人口.
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