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准p53激活:最近在癌症和糖尿病黄斑胀方面的治疗进展

Zhiyi Wang¹, Shijie Zhang², Loïca Mélita Irakoze²

¹School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Rd., Shanghai, 201203, China.

European journal of medicinal chemistry

|July 2, 2025

概括

激活p53,一个关键的瘤抑制剂,显示了癌症治疗的希望. 最近的药物发现工作重点是针对野生类型和突变p53的新疗法,以加强癌症治疗.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
药理学药理学是指药理学的学科.

背景情况:

p53 是一种由TP53基因编码的关键瘤抑制蛋白.
药理上激活p53是治疗人类癌症的验证策略.
在许多恶性瘤中,p53的失调是常见的,导致瘤的发展.

研究的目的:

为提供旨在增强p53功能的最新药物的全面审查.
突出针对野生类型和突变p53.3的治疗方法.
专注于已经进入临床试验的药物或在TP53-突变癌症中恢复p53活性.

主要方法:

最近科学出版物和临床试验数据的文献综述.
专注于新的治疗策略,包括MDM2降解剂,p53稳定剂,基因疗法和MDM2-p53相互作用抑制剂.
对能够在特定癌症情况下恢复p53活性的药物的分析.

主要成果:

自2020年以来,对p53向治疗的药物发现取得了重大进展.
确定几种正在进行或目前正在进行临床试验的新型药物.
对野生类型和突变p53有效的策略的出现,包括TP53突变癌症.

结论:

针对p53的癌症治疗领域正在迅速发展,有望出现新的药物.
最近的突破为治疗TP53突变癌症提供了新的希望.
本综述为基于p53的癌症治疗中正在进行的和未来的药物发现提供了有价值的参考.

关键词:

降解器降解器降解器基因治疗是一种基因疗法.MDM2DM2 在线播放突变的 p53 变种这就是PROTAC.蛋白质与蛋白质的相互作用在 p53 里,p53 是一个 p53 号码.

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