微血管疾病预测2型糖尿病的死亡率和心血管事件:一项回顾性队列研究
Chun-Ta Huang1, Chiao-Ya Chan1, Ming-Chieh Tsai1
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Mackay Memorial Hospital, Taipei City 104217, Taiwan; Department of Medicine, Mackay Medical College, New Taipei City 252005, Taiwan.
Diabetes research and clinical practice
|July 2, 2025
概括
在2型糖尿病患者中,微血管疾病 (MiVD) 的数量与宏血管风险的增加有关. 更多的MiVD导致更高的死亡率和心血管事件,需要个性化预防.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 2型糖尿病 (T2D) 是微血管疾病 (MiVD) 和大血管并发症的主要危险因素.
- 了解MiVD积累对宏血管结果的影响对于T2D患者的风险分层至关重要.
研究的目的:
- 研究2型糖尿病患者中微血管疾病 (MiVDs) 负担与宏血管结果风险之间的关联.
主要方法:
- 分析了2018-2022年台湾质量调查数据集,其中包括4,527名2型糖尿病患者.
- 根据MiVD的数量 (零,一个或两个或更多),患者被分为三组,包括糖尿病病,视网膜病变和神经病变.
- 评估的主要结果是中风,心肌梗塞和所有原因死亡的发病率,平均随访时间为3.3年.
主要成果:
- 主要不良心血管事件的发生率随着MiVDs的数量逐渐增加.
- 与没有MiVDs (组0) 患者相比,患有两种或两种以上MiVDs (组2) 的患者面临的主要结局显著更高的风险 (HR:1.73).
- 第二组还显示,中风 (HR:2.61) 和心肌梗塞 (HR:1.67) 的风险显著增加.
结论:
- 在2型糖尿病患者中,微血管疾病负担的增加与死亡率和主要心血管事件的风险增加有关.
- 这些发现强调了需要量身定制的预防策略,以减轻T2D患者多次微血管并发症的大脑血管风险.
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