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与C反应蛋白相比,系统性免疫炎症指数是他类药物残留心血管风险的预测指标

Yihua Lu¹, Meng Wei¹, Kandi Zhang¹

¹Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

International journal of cardiology

|July 2, 2025

概括

系统性免疫炎症指数 (SII) 预测了他类药物使用者的心血管死亡,其表现优于C反应蛋白 (CRP). 这种新型生物标志物可以识别残留的炎症风险,改善患者的治疗结果.

科学领域:

心血管医学心血管医学
炎症生物标志物炎症生物标志物
公共卫生公共卫生

背景情况:

治疗心血管疾病的他类药物患者仍然存在残留炎症风险.
系统性免疫炎症指数 (SII) 是一个复合生物标志物,反映了系统性炎症和免疫失调.
评估SII对他类药物使用者的残留心血管死亡率的预测能力至关重要.

研究的目的:

评估系统性免疫炎症指数 (SII) 作为治疗他类药物患者心血管死亡率的预测指标.
为了比较SII与C反应蛋白 (CRP) 的预测准确度,以预测残留心血管风险.
确定SII是否是当代他类药物使用者心血管死亡的独立预测因素.

主要方法:

从NHANES (1999-2018) 分析了8211名使用他类药物的成年人,并通过2019年对生存进行了跟踪.
考克斯的比例危险模型用于评估自然日志转换SII (lnSII) 与心血管死亡率之间的关联.
用于比较SII和CRP的预测精度的接收器运行特征 (ROC) 曲线分析.

主要成果:

在同变量调整后,较高的基线SII与心血管死亡风险增加显著相关 (HR,1.241;95% CI,1.009-1.527).
系统性免疫炎症指数 (SII) 与C反应蛋白 (CRP) (AUC,0.749) 相比,显示出更高的预测准确性 (AUC,0.760).
随访显示,8211名参与者中796人死于心血管疾病,平均6.92年.

结论:

系统性免疫炎症指数 (SII) 是当代他类药物治疗患者未来心血管死亡的独立预测指标.
在接受他类药物治疗的个人中,SII在预测残留心血管风险方面超过了CRP.
SII提供了一种有价值的工具,用于识别和管理心血管患者的持续性炎症风险.

关键词:

生物标志物生物标志物心血管疾病是什么心血管疾病剩余的风险剩余的风险史塔丁类药物是一种系统性免疫炎症指数

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