高全静态状态会损害患者的认知功能第一个情节药物原始双极性障碍
SuJuan Li1, XiuShan Chen1, Yan Qiu2
1Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
概括
慢性压力的衡量标准,高静态负荷 (AL) 与首次诊断为双相情感障碍 (BD) 患者的认知障碍有关. 这一发现强调了AL作为BD潜在的因素.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 内分泌学 在内分泌学.
背景情况:
- 双极性障碍 (BD) 经常与认知缺陷有关.
- 静态负荷 (AL) 量化累积的生理压力,并与BD病理生理学有关.
- 了解AL和早期BD的认知之间的联系至关重要.
研究的目的:
- 调查静态负荷 (AL) 与认知功能之间的关系.
- 为了检查首次诊断的,前不用药的双相情感障碍 (BD) 患者.
- 为了比较AL和BD患者和健康对照之间的认知表现.
主要方法:
- 招募了113名BD患者和115名健康对照 (HC).
- 测量生物标志物 (BMI,WHR,脂质,葡萄糖,CRP,皮质醇,DHEA) 来计算AL.
- 通过RBANS和Stroop Word测试评估认知功能;通过HAMD,HAMA,YMRS进行临床症状.
主要成果:
- 与HC相比,BD患者的AL水平显著更高.
- 在RBANS和Stroop测试中,BD患者的认知表现显著下降.
- 皮质醇和CRP水平与记忆表现相关;AL与男性认知得分负相关.
结论:
- 高度的静态负荷可能会导致双相情绪障碍的病理生理学.
- 较高的AL与BD患者的认知能力下降有关.
- 在BD中,AL代表了认知功能障碍的潜在治疗目标.
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