NAD+ 繁殖增强哺乳乳母乳生成和改善后代的发展在一个播种模型
Long Huang1, Chenglin Pan1, Wei Zhang1
1Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, China; Key Laboratory of Animal Disease-Resistant Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Chengdu, China; Key Laboratory of Animal Disease-Resistant Nutrition of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
The Journal of nutrition
|July 2, 2025
概括
尼古丁胺基核酸 (NR) 补充剂可以提高哺乳期乳腺中的尼古丁胺基氨酸二核酸 (NAD+) 水平,增强乳生产和后代生长. 这项研究确定NR是提高哺乳效率的关键因素.
科学领域:
- 生殖生理学 生殖生理学
- 代谢生物化学 代谢生物化学
背景情况:
- 由于缺乏了解乳糖生成机制,哺乳不足是一个临床挑战.
- 尼古丁胺胺氨基二核酸 (NAD+) 正成为生殖生理学的关键调节剂.
研究的目的:
- 为了描述乳腺NAD+代谢.
- 为了评估母体尼古丁胺基核糖胺 (NR) 补充剂对乳腺乳腺生成的影响.
主要方法:
- 20头母猪被分为对照组和NR补充组 (25毫克NR/体重公斤/天).
- 进行了乳腺活检,微透析,牛奶分析和后代生长评估.
- 用t测试和差异的两因素分析分析了数据.
主要成果:
- 补充NR显著增加了乳腺和牛奶的NAD+水平,导致每日牛奶产量增加31%.
- NR增强了乳腺膜发育和乳腺生成基因表达,使后代的断奶体重提高了23%.
- 激活了NAD+-SIRT1信号,增加了线粒体密度和生物发生.
结论:
- 孕产妇的NR补充有效地满足哺乳期乳腺的NAD+需求.
- NR增强乳腺分泌分化和牛奶生物合成,为哺乳不足提供治疗潜力.
- 这项研究确定了改善哺乳期的新生物标志物和治疗点.
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