急性白血病幸存者的生殖模式和出生率:丹麦基于人口的队列研究
Nanna N Nielsen1, Jonas F Jensen1, Andreas Øvlisen1
1Department of Hematology, Clinical Cancer Research Center, Aalborg University, Aalborg, Denmark.
British journal of haematology
|July 2, 2025
概括
年轻的急性白血病幸存者经历了较低的出生率和更高的辅助生殖技术使用. 由于与治疗相关的不孕症风险,生育保护咨询至关重要.
科学领域:
- 在瘤学瘤学.
- 生殖医学 生殖医学
- 流行病学 流行病学
背景情况:
- 与治疗相关的不孕症是年轻急性白血病幸存者的重要关注点.
- 长期幸存者需要全面了解他们的生殖健康后期治疗.
研究的目的:
- 与一般人口相比,评估急性白血病幸存者的出生率和妊娠结果.
- 评估急性白血病幸存者中辅助生殖技术 (ART) 的使用情况.
主要方法:
- 一项队列研究将401名急性白血病幸存者与4010名无白血病的比较者匹配起来.
- 随访时间的中位数为9.9年,分析了出生率,活产的累积发病率和ART使用.
- 在幸存者和对照者之间比较了怀孕结果.
主要成果:
- 经过急性白血病的幸存者出现较低的出生率 (IRR:0.77) 和10年累计活产发病率 (女性:20.1%,男性:22.3%).
- 与对照人群相比,幸存者使用ART的比例明显高 (女性:25.5%,男性:55.9%).
- 在急性白血病幸存者中没有观察到不良妊娠结果的风险增加.
结论:
- 患有急性白血病的幸存者面临生育能力下降和更多地依赖ART.
- 告知患者生育保存选择和不孕症风险是必不可少的.
- 对癌症幸存者生殖健康支持的进一步研究是有必要的.
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