Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Epistasis Analysis01:09

Epistasis Analysis

Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model01:13

Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model

Drugs administered through various routes can lead to nonlinear elimination, resulting in complex pharmacokinetic behaviors crucial to understanding efficacious drug dosing.
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

SOFisher: reinforcement learning-guided experiment designs for spatial omics.

Nature communications·2026
Same author

Benchmarking alignment methods for spatial transcriptomics data.

Nature computational science·2026
Same author

Scalable discovery of spatial multicellular patterns via neighborhood-to-sequence transformation.

Communications biology·2026
Same author

3d-OT: a deep geometry-aware framework for heterogeneous slices alignment of spatial multi-omics.

Nature methods·2026
Same author

Dissecting spatial patterning and signaling with directional diffusion in spatial multi-omics.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

DECODE: deep learning-based common deconvolution framework for various omics data.

Nature methods·2026
Same journal

Demonstration of a quantum C-NOT gate in a time-multiplexed fully reconfigurable photonic processor.

Nature communications·2026
Same journal

Nonlinear quantum light source with van der Waals ferroelectric NbOX<sub>2</sub> (X = Br, I).

Nature communications·2026
Same journal

Antagonistic histone H2A variants and autonomous heterochromatin formation shape epigenomic patterns in Arabidopsis.

Nature communications·2026
Same journal

The long tail of nitrate pollution in groundwater challenges governance of global water quality.

Nature communications·2026
Same journal

Select microbial metabolites promote tau aggregation in a murine tauopathy model.

Nature communications·2026
Same journal

Warming climate has lengthened global intense tropical cyclone seasons.

Nature communications·2026
查看所有相关文章

相关实验视频

Updated: Jun 5, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.3K

使用可解释的深度学习优先考虑对扰动反应的基因模式.

Yan Cui1,2,3, Zhiyuan Yuan4,5,6

  • 1Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.

Nature communications
|July 2, 2025
PubMed
概括
此摘要是机器生成的。

在多种条件下,River 识别了具有差异空间表达模式 (DSEP) 的基因. 这种深度学习框架提供了一个可扩展和可解释的解决方案,用于分析整个组织的基因表达动态.

更多相关视频

Author Spotlight: Advancing Alzheimer's Research &#8211; Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.3K
Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

529

相关实验视频

Last Updated: Jun 5, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.3K
Author Spotlight: Advancing Alzheimer's Research &#8211; Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.3K
Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

529

科学领域:

  • 基因组学就是基因组学.
  • 计算生物学 计算生物学
  • 系统生物学 系统生物学

背景情况:

  • 空间分辨的转录组学在组织环境中映射基因表达.
  • 现有的方法侧重于单片空间变化,限制了交叉条件分析.
  • 在复杂的生物学研究中,识别各种条件的差异空间表达模式 (DSEPs) 是至关重要的.

研究的目的:

  • 介绍DSEP基因优先级作为一个新的分析任务.
  • 现在河,一个深度学习框架,用于识别条件相关的空间基因表达变化.
  • 为多条件空间转录学分析提供可扩展和可解释的解决方案.

主要方法:

  • 开发了River,这是一个具有双分支预测架构的深度学习框架.
  • 实施了后期归因策略,根据对条件差异的贡献对基因进行排序.
  • 集成空间信息化建模和分离空间/非空间组件,以实现可扩展性和可解释性.

主要成果:

  • 在不同的生物环境中,River成功地识别了具有DSEP的基因.
  • 向大型空间数据集展示了可扩展性和与各种数据类型的兼容性.
  • 应用于胚胎发生,糖尿病,狼和三阴性乳腺癌,揭示了特定条件的空间模式.

结论:

  • 河提供了一种灵活和可扩展的解决方案,用于分析跨多种生物条件的组织范围的表达动态.
  • 该框架优先考虑了在三阴性乳腺癌中与生存相关的空间模式,这些模式在患者中普遍存在.
  • 河流推进了复杂的空间转录学数据的分析,使新的生物发现成为可能.