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种族中立与种族特定的GLI参考方程关于一般人口中螺旋测量解释的参考方程

Joon Young Choi¹, Chin Kook Rhee², Yong Suk Jo²

¹Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Scientific reports

|July 2, 2025

概括

新的种族中立的2022年全球肺功能倡议 (GLI) 方程减少了东北亚人的肺功能障碍诊断,但显示下降速度更快. 在改变螺旋测量解释方法时建议谨慎.

科学领域:

肺部医学肺部医学
呼吸系统生理学呼吸系统生理学
临床流行病学临床流行病学

背景情况:

解释肺功能对于诊断和管理呼吸系统疾病至关重要.
全球肺功能倡议 (GLI) 已将其螺旋计参考方程从种族特定 (2012) 演变为种族中立 (2022).

研究的目的:

评估从2012年种族特定的GLI过渡到2022年种族中立的GLI参考方程对东北亚人的螺旋测量解释的影响.
评估肺功能障碍,医疗残疾分类和纵向肺功能轨迹的变化.

主要方法:

利用了来自KoGES队列中的10,030名成年人的螺旋计数据.
使用2012年种族特定和2022年种族中立的GLI参考方程来得出百分比预测值.
分析了肺功能障碍的患病率,医疗残疾,与呼吸系统症状的关联,以及肺功能下降率.

主要成果:

在两个GLI方程集之间观察到中等到几乎完美的一致性,用于损伤和残疾分类.
2022年种族中立方程将48.9%和39.9%的患者重新分类为正常的肺生理或较轻重的残疾.
虽然症状关联保持一致,但2022年方程表明FEV1和FVC的纵向下降速度更快 (p < 0.001).

结论:

转向种族中立的2022年GLI方程减少了东北亚人的肺功能障碍和医疗残疾分类.
在新的方程中观察到不同程度的肺功能下降,尽管症状相关性一致.
在采用新的肺功能解释方法时需要仔细考虑,因为在不同人群中存在差异性影响.

关键词:

慢性阻塞性肺病是一种慢性阻塞性肺病.群组研究是一项群组研究.在 GLI 参考方程中,肺功能肺功能肺功能种族差异是种族差异.

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