根据NHANESES的数据,乙型肝炎疫苗接种和听力损失之间的频率相关性
Rong-Jing Qie1, Jiang-Bo Qin2, Zhong-Hao Ji3,4
1Department of Otorhinolaryngology Head and Neck Surgery, Changzhi People's Hospital, Changzhi Medical College, Changzhi, 046000, Shanxi, China.
Scientific reports
|July 2, 2025
概括
乙型肝炎疫苗可能会防止语音频率听力损失,而乙型肝炎疫苗可能会增加右耳的低频听力问题. 需要进一步的研究.
科学领域:
- 听力学 听力学是指听力学.
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 听力损失是一个重大的公共卫生问题.
- 疫苗接种状态是一个可改变的因素,可能会影响健康结果.
- 甲型肝炎和乙型肝炎疫苗接种与听力健康之间的关系尚未得到充分证实.
研究的目的:
- 调查甲型肝炎和乙型肝炎疫苗接种状态与听力损失之间的关联,包括纯色调平均 (PTA).
- 探索这些疫苗在不同的人口群体的听力上的潜在差异性影响.
主要方法:
- 从2011-2012年和2015-2016年NHANES中分析了5553名美国成年人 (20-69岁) 的数据.
- 使用多变量回归模型来评估疫苗接种状态对听力损失和PTA的影响,并对混因素进行调整.
- 进行中介分析以探索潜在的机制,如抗体水平.
主要成果:
- 2剂以上的甲型肝炎疫苗与语音频率听力损失 (OR 0.76) 相反相关.
- 乙肝疫苗≥3剂与右耳低频率PTA (β1.22) 有正相关性.
- 在女性和西班牙裔人群中,甲型肝炎疫苗的益处显著;乙型肝炎疫苗的影响在非西班牙裔白人,已婚个人和吸烟者中更为明显.
结论:
- 适当的甲型肝炎疫苗接种可以提供对言语频率听力损失的保护.
- 乙型肝炎疫苗接种可能与右耳中低频PTA增加有关.
- 研究结果表明,需要针对接种疫苗的人群进行有针对性的听力健康监测,并进一步调查潜在机制.
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