乳球球菌cremoris YRC3780在Uchida-Kraepelin测试中改善主观应激反应:一种随机,双盲,安慰剂控制的随机研究
1R&D Center, Yotsuba Milk Products Co., Ltd, 465-1 Wattsu, Kitahiroshima, Hokkaido, 061-1264, Japan.
Scientific reports
|July 2, 2025
概括
乳球球菌cremoris YRC3780补充剂改善了健康成年人的心理应激反应. 这种益生菌干预显著减少了经过长达八周的压力测试后的情绪障碍.
科学领域:
- 微生物学 微生物学
- 心理神经免疫学 心理神经免疫学
- 人类营养人类营养
背景情况:
- 肠道微生物组影响大脑-肠道轴.
- 心理压力会影响下丘脑-垂体-上腺 (HPA) 轴.
- 益生菌可以通过免疫路径调节压力反应.
研究的目的:
- 评估乳球球菌cremoris YRC3780对心理应激反应的疗效.
- 评估YRC3780每日摄入量对健康成年人情绪障碍的影响.
主要方法:
- 随机,安慰剂控制,双盲,并行组研究.
- 107名健康的日本成年人最初呈阳性Uchida-Kraepelin (U-K) 测试应激反应.
- 用YRC3780或安慰剂进行干预,持续8周,评估POMS2分数的U-K前后测试.
主要成果:
- 与安慰剂相比,YRC3780组在U-K测试后的POMS2总情绪障碍 (TMD) 评分显著改善.
- 在8周后,在YRC3780组中观察到POMS2TMD和5个子评分的显著改善.
- 每日YRC3780摄入量对应激反应产生了显著的积极影响.
结论:
- 乳球球菌YRC3780有效地改善了健康的日本成年人的心理应激反应.
- 益生菌可能调节HPA轴对急性心理压力的反应.
- 每天摄入YRC3780为压力管理提供了一个潜在的策略.
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