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慢性失眠中国家特定的乳头部调节障碍是由动态边缘中心功能连接性揭示的

Hancheng Ma¹, Xue Zhang², Xiaoran Ma¹

¹Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, 266590, Shandong, China.

Scientific reports

|July 2, 2025

概括

慢性失眠 (CI) 涉及到大脑网络连接的改变,特别是在 thalamus-mediated 途径. 动态功能连接分析揭示了异常的大脑状态,并将它们与CI患者的睡眠和焦虑症状联系起来.

科学领域:

神经科学是一个神经科学.
认知神经科学认知神经科学
医疗成像医学成像

背景情况:

慢性失眠 (CI) 与广泛的神经失调有关.
了解CI中大脑网络变化的动态性质对于开发有针对性的干预措施至关重要.
丘陵体在传递感官信息和调节意识方面发挥着关键作用,使其成为大脑网络动态中的关键节点.

研究的目的:

通过使用动态边缘功能连接 (deFC) 来研究慢性失眠 (CI) 中的动态皮质-thalamocortical-subcortical网络调节障碍.
为了识别由丘脑介导的短暂连接状态及其在CI中的临床相关性.
探索CI患者与健康对照者 (HCs) 相比,大脑网络的时间动态.

主要方法:

休息状态功能磁共振成像 (fMRI) 对30名CI患者和32名HC患者进行.
计算了动态边缘功能连接 (deFC),其中以丘脑作为枢纽节点来计算.
使用K-means集群来识别短暂的连接状态,并分析了时间属性和边缘功能连接 (eFC) 的群体差异. 临床评估包括匹兹堡睡眠质量指数 (PSQI) 和自我评价焦虑量表 (SAS).

主要成果:

在CI和HC组之间的动态功能网络的时间属性 (过渡数,分数时间,平均停留时间) 中没有发现显著差异.
四个不同的动态大脑状态在CI和HC组之间表现出显著的eFC异常 (p < 0.0001,FDR校正).
在各州观察到 thalamic 主导的半球不对称性,并且特定的异常eFC 与CI组的PSQI和SAS得分有显著的相关性.

结论:

动态功能连接分析揭示了在经半球不对称性为特征的慢性失眠中,thalamic介导eFC的状态特定变化.
这些发现为与失眠相关的神经变化提供了一个时间网络视角.
thalamus介导连接的异常与CI中睡眠质量差和焦虑的临床症状有关.

关键词:

慢性失眠症是什么慢性失眠症边缘功能连接的功能连接泰拉姆斯 (thalamus) 是一个神经元.功能磁力共振成像 (fMRI) 是一种功能共振成像.

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