同型RNA聚类伴随着多元组分生物分子凝聚物的核心内液体到固体的过渡
Tharun Selvam Mahendran1, Gable M Wadsworth2, Anurag Singh2
1Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, NY, USA.
Nature chemistry
|July 2, 2025
概括
生物分子凝聚物可以驱动RNA聚合,形成不同的结构. 像G3BP1这样的RNA结合蛋白质充当伴侣,防止神经疾病中有害的RNA聚类.
科学领域:
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
- 神经科学是一个神经科学.
背景情况:
- 由RNA驱动的凝结组织了细胞的核糖核蛋白颗粒.
- 重复扩展RNA的异常聚合与神经系统疾病有关.
研究的目的:
- 研究生物分子凝聚物在不可逆转的RNA聚合中的作用.
- 了解防止异常RNA相位过渡的机制.
主要方法:
- 在多元组件生物分子凝聚物中研究重复RNA.
- 分析了G3BP1对RNA聚类的影响.
- 研究的ATP独立机制.
主要成果:
- 重复RNA在凝聚物中经历年龄依赖的聚类,形成纳米级的聚类.
- 聚类导致具有固体RNA丰富核和流体外的多相凝聚物.
- 通过缓冲RNA-RNA相互作用,G3BP1可以防止RNA聚类.
结论:
- 生物分子凝聚物可以作为RNA聚合的地点.
- RNA结合蛋白对异常的RNA相转换具有伴侣式的功能.
- 这些发现提供了对神经系统疾病病原体的见解.
相关概念视频
Noncovalent Attractions in Biomolecules
18.5K
18.5K
Phase Transitions: Vaporization and Condensation
18.8K
The physical form of a substance changes on changing its temperature. For example, raising the temperature of a liquid causes the liquid to vaporize (convert into vapor). The process is called vaporization—a surface phenomenon. Vaporization occurs when the thermal motion of the molecules overcome the intermolecular forces, and the molecules (at the surface) escape into the gaseous state. When a liquid vaporizes in a closed container, gas molecules cannot escape. As these gas phase...
18.8K
The Fluid Mosaic Model
154.3K
The fluid mosaic model was first proposed as a visual representation of research observations. The model comprises the composition and dynamics of membranes and serves as a foundation for future membrane-related studies. The model depicts the structure of the plasma membrane with a variety of components, which include phospholipids, proteins, and carbohydrates. These integral molecules are loosely bound, defining the cell’s border and providing fluidity for optimal function.
154.3K
Fluid Mosaic Model
13.0K
Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich...
13.0K
RNA Stability
33.9K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
33.9K
Membrane Fluidity
157.1K
Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
157.1K


