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Updated: May 11, 2026

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单细胞Micro-C在高分辨率下对3D基因组结构进行分析,并对多增强器枢纽进行特征化

Honggui Wu1,2,3, Jiankun Zhang1,2, Longzhi Tan4

  • 1Biomedical Pioneering Innovation Center (BIOPIC) and School of Life Sciences, Peking University, Beijing, China.

Nature genetics
|July 2, 2025
PubMed
概括

研究人员开发了单细胞Micro-C (scMicro-C) 来绘制3D基因组图. 这项技术揭示了促进剂增强剂条纹 (PESs),这些条纹是空间组织多种增强剂以调节基因表达的结构.

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相关概念视频

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...