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Updated: Sep 17, 2025

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

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以生理学为基础的药理动力学建模为基础的评估当前的Carbamazepine和瓦尔酸剂量指南为治疗儿科的治疗指南

Joyce E M van der Heijden1, Violette Gijsen1, Anne M van Uden1

  • 1Division of Pharmacology and Toxicology, Department of Pharmacy, Pharmacology Toxicology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.

Paediatric drugs
|July 2, 2025
PubMed
概括

基于生理学的药理动力学 (PBPK) 建模优化了卡巴马泽和酸 (VPA) 的儿科剂量. 模拟支持目前的建议,但建议对新生儿和青少年进行剂量调整,并监测低albuminemic 患者的未结合VPA.

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Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
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