满足运动指南对多发性硬化症中抑郁和焦虑的影响 - 一个系统性审查和元分析
Sodiq Fakorede1, Joseph Peters2, Tanner Murphy2
1Department of Physical Therapy, Rehabilitation Science, and Athletic Training, University of Kansas Medical Center, Kansas City, KS, USA.
Physiotherapy theory and practice
|July 2, 2025
概括
遵守多发性硬化症 (PAG-MS) 身体活动指南显著改善了MS (PwMS) 患者的抑郁症. 虽然焦虑的益处尚不清楚,但PAG-MS运动是一种有前途的非药物治疗方法.
科学领域:
- 神经学 神经学
- 运动科学 运动科学
- 心理健康研究 心理健康研究
背景情况:
- 抑郁和焦虑在多发性硬化症 (MS) 中很普遍,影响生活质量.
- 之前在患有多发性硬化症 (PwMS) 的人群中,针对心理健康的运动干预措施产生了不一致的结果,通常是由于对指导方针的不严格遵守.
- 多发性硬化症体育活动指南 (PAG-MS) 提供了PwMS运动的框架.
研究的目的:
- 评估PAG-MS符合运动对MS患者抑郁和焦虑的影响.
- 根据已确定的临床重要差异最小值 (MCID) 值,确定运动干预措施的临床意义.
主要方法:
- 一个系统的审查和随机对照试验 (RCTs) 的元分析,发表到2024年10月.
- 在多个数据库进行搜索,包括PubMed,EMBASE和Web of Science.
- 包括专注于患有多发性硬化症的成年人的研究,将PAG-MS合规的运动与不合规的运动或没有运动进行比较,并分析抑郁和焦虑结果.
主要成果:
- 分析了12个带有458名参与者的RCT.
- 观察到抑郁症的显著改善 (MD: -4.46,P < 0.01),超过贝克抑郁症库存的MCID.
- 两项RCT的焦虑结果显示没有显著的改善 (SMD: -0.87,p = .29).
- 在58.33%的纳入研究中发现了高偏差风险.
结论:
- 与PAG-MS一致的运动干预措施在PwMS中为抑郁症提供了临床上有意义的好处.
- 符合PAG-MS的运动是一种可行的非药物治疗方案,用于MS的抑郁症.
- 由于目前的数据有限,需要进一步研究以阐明PAG-MS运动对PwMS中焦虑症状的影响.
相关概念视频
01:25Stress Prevention and Stress Management Techniques III
110
Regular exercise and meditation serve as essential tools in managing stress and promoting physical and mental well-being.
The Role of Exercise in Stress Management
Regular physical activity is essential for reducing stress and promoting cardiovascular health. Exercise strengthens the heart, enhances blood flow, keeps blood vessels flexible, and helps lower blood pressure, all of which reduce the body's stress response. Research shows that adults who exercise regularly have nearly half the...
The Role of Exercise in Stress Management
Regular physical activity is essential for reducing stress and promoting cardiovascular health. Exercise strengthens the heart, enhances blood flow, keeps blood vessels flexible, and helps lower blood pressure, all of which reduce the body's stress response. Research shows that adults who exercise regularly have nearly half the...
110
01:30Generalized Anxiety Disorder
214
Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...
214
01:18Depression: Overview
361
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
361
01:17Exercise and Cardiac Output
1.3K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
Sustained exercise increases the muscles' oxygen demand, which can be...
1.3K
01:18Anxiety: Overview
374
Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
374
01:20Exercise and Cardiovascular Response
1.1K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
1.1K