鼻微生物组的组成由SARS-CoV-2的存在和严重程度
Juana Claus1, Janetta Top2, Fernanda L Paganelli2,3
1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Scientific reports
|July 2, 2025
概括
SARS-CoV-2 病毒可能会在鼻子中略微增加Corynebacterium 细菌,但随着COVID-19 疾病变得更严重,Dolosigranulum 细菌会减少. 鼻微生物群受到伴随性疾病的影响.
科学领域:
- 微生物学 微生物学
- 病毒学 病毒学
- 人类微生物组 人类微生物组
背景情况:
- 在SARS-CoV-2感染和鼻微生物组之间的关系仍然在很大程度上未被探索.
- 了解这种相互作用对于理解COVID-19病原和宿主反应至关重要.
研究的目的:
- 调查SARS-CoV-2对鼻微生物组合和细菌度的影响.
- 探索SARS-CoV-2和鼻细菌之间的潜在双向相互作用.
主要方法:
- 来自荷兰卫生保健工作者和呼吸器门诊患者的鼻抽样使用16S rRNA amplicon测序进行了分析.
- 样本被测试SARS-CoV-2和其他呼吸道病毒使用多重PCR.
- 细菌估计度 (ECs) 与病毒存在和疾病严重程度相关.
主要成果:
- 在医疗保健工作者中,SARS-CoV-2存在与Corynebacterium ECs略有增加相关.
- 与未感染的对照人群相比,无症状的SARS-CoV-2病例中的dolosigranulumECs较高,但随着COVID-19严重程度的增加而下降.
- 患者的鼻微生物组组成主要受到伴随性疾病的影响,而不是SARS-CoV-2的严重程度.
结论:
- 随着SARS-CoV-2严重程度的增加,dolosigranulum ECs可能会减少,尽管临床意义尚不确定.
- 伴随性疾病在患有呼吸道症状的患者中显著塑造鼻微生物群.
- 需要进一步的研究来阐明COVID-19中观察到的微生物组变化的临床相关性.
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