在中国的一项基于人口的队列研究中,妊娠期体重增加模式与早产子类型的关联
Yiyang Guo1, Kai Chen1, Jin'e Zhang1
1Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Scientific reports
|July 2, 2025
概括
优化妊娠期体重增加 (GWG) 对于预防早产 (PTB) 亚型至关重要. 不足和过度GWG,特别是早期GWG,在各种妊娠前BMI类别中增加PTB风险.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 公共卫生 公共卫生
背景情况:
- 孕期体重增加 (GWG) 是妊娠结果的一个关键因素.
- 过早分娩 (PTB) 仍然是新生儿发病率和死亡率的主要原因.
- 了解GWG模式与特定的PTB亚型之间的关联对于有针对性的干预至关重要.
研究的目的:
- 调查不同妊娠体重增加 (GWG) 模式和早产分型 (PTB) 之间的关系.
- 分析这些协会在各种怀孕前的体重指数 (BMI) 类别.
- 为个人化产前体重管理策略提供信息,以减少PTB风险.
主要方法:
- 利用了来自中国武汉的57,138名单身分娩的数据.
- 根据中国的指导方针和每周的增量,分类总量GWG和早期GWG (eGWG).
- 采用多重逻辑回归分析,调整共变量,并根据怀孕前的BMI进行子组分析.
主要成果:
- 体重不足的女性过度GWG或高eGWG面临所有PTB亚型的风险增加.
- 体重正常的女性表现出PTB风险升高,其eGWG过高/高,eGWG不足/低.
- 体重过重/肥胖,eGWG不足/低的女性患自发PTB和早产前膜破裂 (PPROM) 的风险更高.
结论:
- 优化GWG对于减轻所有妊娠前BMI类别的PTB风险至关重要.
- 特定的GWG模式 (不足,过度,早期增益) 与PTB亚型有差异性关联.
- 定制的产前体重管理策略是必要的,以改善妊娠结果和减少PTB发生率.
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