血清布基胆酶活性作为COVID-19患者严重程度和死亡率的预测指标
Tomáš Fazekaš1, Lucia Kováčik2, Morteza Motahari Rad2
1Department of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University Bratislava, Odbojarov 10, Bratislava, 832 32, Slovakia.
Scientific reports
|July 2, 2025
概括
丁胆酶 (BChE) 活性与COVID-19的严重程度和死亡率有关. 较低的BChE水平与严重的症状,呼吸系统问题和增加的死亡率相关,而较高的水平与神经症状有关. 年龄和疫苗接种情况也会影响BCHE活动.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 乙基胆酶 (BChE) 在胆性抗炎途径中发挥作用.
- 以前的研究表明,BCHE,炎症和COVID-19结果之间存在潜在联系.
- 需要进一步调查,以了解BCHE在COVID-19严重性中的作用,同时考虑人口统计和临床因素.
研究的目的:
- 调查丁胆酶 (BChE) 活性与COVID-19严重程度之间的关联.
- 检查年龄,性别,疫苗接种情况和症状概况对COVID-19患者BChE活动的影响.
- 为了确定BCHE活动是否可以作为COVID-19的预后生物标志物.
主要方法:
- 对来自西班牙第一波流行病的462名PCR确诊的COVID-19患者的分析.
- 测量血清BChE活动.
- BChE活动与临床结果,人口因素 (年龄,性别),疫苗接种状态和症状概况 (呼吸,神经,胃肠道等) 的相关性. ) 的情况.
主要成果:
- 随着年龄的增长,BCHE活性显著下降,但不受性别的影响.
- 在患有严重/危急COVID-19和呼吸系统症状 (肺炎,呼吸障碍) 的患者中观察到较低的BCHE活性.
- 较高的BChE活性与神经症状 (厌氧,衰老,头痛) 有关,接种疫苗的个体表现出较低的BChE活性.
结论:
- 血清BChE活性与COVID-19的严重程度,死亡率和特定症状显著相关.
- 年龄和疫苗接种状态是影响COVID-19患者BCHE活性的重要因素.
- BChE可能作为COVID-19的预后和风险分层的潜在生物标志物,保证对其临床应用进行进一步研究.
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