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细胞因子和维生素D在良性和恶性甲状腺疾病中的差异表达

Huimin Li¹, Xin Jin¹, Meng Zhang¹

¹Department of Laboratory, Tongde Hospital of Zhejiang Province, Hangzhou, 310012, Zhejiang, China.

Scientific reports

|July 3, 2025

概括

这项研究揭示了甲状腺结核中细胞因子的升高和维生素D的降低,特别是乳头甲状腺癌 (PTC). 维生素D作为一种保护因素,而IL-17可能表明恶性瘤的风险,建议结合检测以改善诊断.

科学领域:

内分泌学和免疫学的内分泌学和免疫学.
在瘤学瘤学.
分子生物学分子生物学

背景情况:

细胞因子在调节瘤微环境方面发挥着至关重要的作用.
维生素D具有抗炎和抗瘤的特性.
了解细胞因子和维生素D之间的相互作用对于甲状腺疾病的进展至关重要.

研究的目的:

评估关键细胞因子 (IL-4,IL-6,IL-10,IL-17,TNF-α,IFN-γ) 和维生素D的血清水平.
为了比较患有良性甲状腺结节,乳头甲状腺癌 (PTC) 和健康对照患者的这些水平.
为了阐明这些标记物在甲状腺疾病进展中的参与.

主要方法:

从24名良性结节患者,39名PTC患者和35名健康对照人群中采集了周围血液样本.
使用流式细胞计量测量血清细胞因子水平.
血清维生素D水平通过化学发光免疫测试来确定.

主要成果:

与对照组和良性结节患者相比,PTC患者的IL-4,IL-6,IL-10,IL-17,TNF-α和IFN-γ水平显著更高.
在PTC患者中,维生素D水平显著降低.
血清IL-17和维生素D水平在良性和恶性甲状腺结节之间表现出良好的区分能力.
维生素D是对恶性甲状腺结节的独立保护因素,而IL-17显示出成为危险因素的趋势.

结论:

上调的细胞因子表达和维生素D缺乏与甲状腺疾病有关,特别是PTC.
血清IL-17和维生素D的联合检测可能有助于预测结节性甲状腺疾病中的恶性瘤风险.
这些发现为开发用于甲状腺癌诊断的新型生物标志物面板提供了指导.

关键词:

良性甲状腺结块是一种良性甲状腺结块.在IFN-γγ中.在 IL-10 中,IL-10 是 IL-10 的代表.它们的IL-17和IL-17.IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-4-IL-IL-4-IL-4-IL-4-IL-4-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL-IL is is is is is what is what is what is what is what is what is 在IL-6的研究中,IL-6被认为是IL-6的基因.在PTC中使用PTC.这就是TNF-α.维生素D 维生素D是一种维生素.

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