腹部和部脂肪百分比与脆弱性骨折有关:来自大型横截面研究的证据
Hamzah Amin1, Muhammed Aqib Khan2, Marwan Bukhari3
1Lancaster University Medical School, Sir John Fisher Drive, Lancaster, LA1 4YW, UK. h.amin1@lancaster.ac.uk.
Scientific reports
|July 3, 2025
概括
通过DXA扫描测量的身体脂肪分布影响骨折风险. 下腹部和部脂肪与骨折几率降低相关,而较高的脂肪百分比增加骨折风险,表明区域性身体组成作为一种新的预测因素.
科学领域:
- 骨健康和骨质疏松症研究
- 医学成像和诊断 医学成像和诊断
- 身体组成分析分析.
背景情况:
- 身体脂肪的分布越来越被认为是影响骨健康的因素.
- 以前的研究还没有完全阐明DXA评估的区域体脂组成与脆弱性骨折之间的关系.
- 了解这些关联对于改善骨折风险预测模型至关重要.
研究的目的:
- 调查DXA衍生的区域身体脂肪百分比 (腹部,左,右) 与部和任何脆弱性骨折的风险之间的关联.
- 为了确定区域性身体组成是否是骨折风险的独立预测因素,超出已确定的临床因素.
- 分析脂肪分布对各种骨折类型的差异影响.
主要方法:
- 从2004年6月到2024年2月,对36,235名患者的DXA扫描 (腰椎和大腿骨) 的分析.
- 腹部,左部和右部脂肪百分比的分类 (低,中,高).
- 多变量后勤回归模型根据FRAX临床因素进行调整,以评估骨折风险 (部或任何脆弱性骨折).
主要成果:
- 腹部脂肪较低的三角形与任何骨折的几率降低有关,而较高的三角形增加了这些几率.
- 左部脂肪的下层三角质与任何骨折的几率降低有关;更高的三角质增加了任何和部骨折的几率.
- 右部脂肪的较低部与部和任何骨折的几率降低有关;较高的部增加了两者的几率.
- 腹部脂肪的最高三位数与关节骨折风险没有显著关联.
结论:
- 由DXA衍生的区域性身体组成,特别是腹部和部的脂肪分布,可能成为部和整体脆弱性骨折的新预测因素.
- 这些发现凸显了在骨折风险评估中考虑区域性身体脂肪的重要性.
- 需要进一步的研究来验证这些关联,并探索潜在的机制.
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