在糖尿病足部感染中对病原性微生物的表征和风险预测模型的开发
Shufang Yan1, Xuemeng Zhu1, Tong Yu1
1Department of Endocrinology, Henan University Huaihe Hospital, Kaifeng, 475500, Henan, China.
Scientific reports
|July 3, 2025
概括
糖尿病足部感染 (DFI) 很常见,主要是由格兰阳性菌引起的. 一种使用年龄,C反应蛋白,瓦格纳等级,下肢动脉疾病和外围神经病变的新型诺莫грам,有助于早期DFI的检测和治疗.
科学领域:
- 微生物学 微生物学
- 临床医学 临床医学
- 生物统计学 生物统计学
背景情况:
- 糖尿病足部感染 (DFI) 是糖尿病的一个严重并发症.
- 准确识别致病原体和早期预测DFI对于有效治疗至关重要.
研究的目的:
- 为了确定病原性微生物在DFI中的分布.
- 开发和验证DFI的预测名录.
主要方法:
- 对136名糖尿病足患者的回顾性分析.
- 感染样本的微生物学分析.
- 开发和验证一个包含临床和实验室参数 (年龄,CRP,瓦格纳等级,LEAD,PN) 的名录.
主要成果:
- 在研究队列中观察到高感染率 (63.23%).
- 格拉姆阳性 (54.65%) 是主要的病原体,其次是格拉姆阴性菌根 (43.02%).
- 开发的名图表显示出强大的预测准确性 (AUC = 0.803) 和良好的适合性.
结论:
- 格拉姆阳性菌是DFI的主要原因.
- 经过验证的nomogram为早期DFI查提供了可靠的工具.
- 及时检测有助于及时的抗生素治疗,改善糖尿病足患者的临床结果.
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