Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Crossing Over01:34

Crossing Over

148.0K
Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
148.0K
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

2.3K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.3K
Hybrid Zones02:29

Hybrid Zones

20.3K
Hybrid zones are narrow regions where two closely related species interact, mate, and produce hybrids. Relative to either parent species, hybrids may possess distinct phenotypic or genetic differences that impact their survival and reproductive success. The genetic variances introduced by hybridization influence species diversity and speciation processes within the hybrid zone.
20.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Long-read Sequencing: from Complete Molecules to Context-resolved Biology.

Genomics, proteomics & bioinformatics·2026
Same author

Single-cell DNA methylation analysis uncovers epigenetic pathways in the transformation of MDS to AML.

Leukemia·2026
Same author

Harmonizing standards and resources for the medical genome.

Nature·2026
Same author

Tranquillyzer: A Neural Network Framework for Long-read Annotation and Demultiplexing.

Genomics, proteomics & bioinformatics·2026
Same author

Evolutionary dynamics of Respiratory Syncytial Virus in pre-pandemic, pandemic, and post-pandemic periods in Houston, Texas, USA.

bioRxiv : the preprint server for biology·2026
Same author

Biological aging and generational shifts in early-onset cancer risk.

Nature medicine·2026

相关实验视频

Updated: Sep 17, 2025

Generation of Integration-free Human Induced Pluripotent Stem Cells Using Hair-derived Keratinocytes
08:36

Generation of Integration-free Human Induced Pluripotent Stem Cells Using Hair-derived Keratinocytes

Published on: August 20, 2015

11.7K

人体组织网络中的体质马赛克

Tim H H Coorens1,2, Ji Won Oh3,4, Yujin Angelina Choi5

  • 1Broad Institute of MIT and Harvard, Cambridge, MA, USA. tcoorens@broadinstitute.org.

Nature
|July 3, 2025
PubMed
概括

这项研究对健康人体组织的体质突变进行了分类,以了解它们的模式和后果. 开发新技术可以改善对这些DNA变异的检测,

更多相关视频

Characterizing Mutational Load and Clonal Composition of Human Blood
07:58

Characterizing Mutational Load and Clonal Composition of Human Blood

Published on: July 11, 2019

7.5K
Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
09:35

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Published on: April 20, 2021

6.9K

相关实验视频

Last Updated: Sep 17, 2025

Generation of Integration-free Human Induced Pluripotent Stem Cells Using Hair-derived Keratinocytes
08:36

Generation of Integration-free Human Induced Pluripotent Stem Cells Using Hair-derived Keratinocytes

Published on: August 20, 2015

11.7K
Characterizing Mutational Load and Clonal Composition of Human Blood
07:58

Characterizing Mutational Load and Clonal Composition of Human Blood

Published on: July 11, 2019

7.5K
Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
09:35

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Published on: April 20, 2021

6.9K

科学领域:

  • 基因组学
  • 人类生物学
  • 分子生物学

背景情况:

  • 身体突变是受精后获得的DNA变异,由于复制错误或变异原体而发生.
  • 在健康组织中理解体质突变的频率,类型和模式是有限的.
  • 与遗传变异相比,检测低比例的体质变异具有挑战性.

研究的目的:

  • 在150名健康捐赠者的19个人体组织部位创建体质突变和克隆模式的参考目录.
  • 开发用于体变异检测的先进技术和计算工具.
  • 评估体质突变的表型后果,包括克隆扩张.

主要方法:

  • 在人体组织网络中建立了体质马赛克.
  • 从19种组织类型中收集了150名无病人的样本.
  • 为体变异和克隆架构开发了新的检测和分析方法.

主要成果:

  • 在各种人体组织中产生了体质突变的综合目录.
  • 鉴定出不同的体质突变和克隆扩张模式.
  • 确定了健康个体体内突变分析的基线.

结论:

  • 提供对人体突变格局的基本理解.
  • 能够与各种疾病的体质突变模式进行比较.
  • 有助于更深入地了解整个生命周期,衰老和疾病中的体质突变和克隆扩张.