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远部内动脉的形态特征与慢性饮酒后大脑的结构变化有关

Cuiqin Wang¹, Yanjie Jia², Longbin Jia³

¹Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.

Scientific reports

|July 3, 2025

概括

慢性饮酒会在灰质体体积变化明显之前改变大脑水分扩散和脑血管形态. 这些发现凸显了酒精的早期大脑变化.

科学领域:

神经成像是一种神经成像.
血管神经学血管神经学
成研究研究成研究

背景情况:

慢性饮酒与显著的神经系统缺陷有关.
了解酒精导致的大脑早期结构和血管变化对于及时干预至关重要.

研究的目的:

研究慢性酒精消费者的结构性大脑变化,明显扩散系数 (ADC) 值和内动脉形态.
为了确定脑血管变化是否先于灰质体积变化.

主要方法:

利用大脑图谱 (Brainnetome Atlas) 进行详细的大脑细分 (246个区域).
在50名慢性酒者和43名非酒者之间,比较了明显扩散系数 (ADC) 值和脑血管形态 (动脉密度,半径,扭曲度,灵活性,长度).
进行了酒精消费,大脑体积和血管参数之间的相关性分析.

主要成果:

与对照人群相比,在134个酒者的大脑区域中观察到显著更高的ADC值.
酒精患者的平均动脉密度,半径和扭曲度降低,动脉灵活性增加.
酒精消费与动脉密度和长度有负相关;大脑体积与血管指标相关.

结论:

慢性酒者脑水扩散发生变化,通常在可检测的灰质结构变化之前发生.
远端内动脉形态的变化有助于在酒精中观察到的大脑结构变化.
这些发现表明,慢性酒会导致早期,微妙的脑部变化.

关键词:

测量ADC的测量结果长期的酒精消费长期的酒精消费远距离的内动脉.形态特征的形态表征.结构性大脑变化结构性大脑变化

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