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相关概念视频

Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
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Role of Vitamins in Maintaining Bone Health01:25

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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The Bone Matrix01:18

The Bone Matrix

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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
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骨代谢 - 一个被低估的参与者

In Ah Choi1,2, Akio Umemoto1, Masataka Mizuno1

  • 1Arthritis and Tissue Degeneration Program, David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, 10021, USA.

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细胞代谢是骨重塑和适应的关键. 了解骨细胞 (骨质细胞,骨质母细胞,骨细胞) 中的代谢重编程,为骨疾病提供了新的治疗点.

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科学领域:

  • 骨生物学和细胞代谢.

背景情况:

  • 骨重塑涉及骨质细胞,骨质母细胞和骨质细胞.
  • 细胞代谢影响骨细胞功能和适应微环境变化.
  • 骨代谢影响全身能量代谢.

研究的目的:

  • 在生理条件下阐明骨细胞之间代谢过程的协调.
  • 了解骨细胞代谢的改变如何导致病理状况.
  • 通过了解不同的代谢需求来确定骨疾病的新疗法策略.

主要方法:

  • 关于最近细胞代谢研究在骨生物学方面的进展的综述.
  • 讨论骨质细胞,骨质母细胞和骨质细胞中的代谢重编程.

主要成果:

  • 细胞代谢是骨细胞分化和功能的组成部分.
  • 骨细胞中的代谢重编程对于适应骨微环境至关重要.
  • 骨细胞中失调的新陈代谢与病理条件有关.

结论:

  • 更深入地了解骨细胞代谢对于治疗骨疾病至关重要.
  • 针对骨细胞中的代谢途径提供了有前途的治疗途径.