阿司匹林可以降低与COVID-19相关的2型糖尿病风险
Valentina Trimarco1, Raffaele Izzo2, Daniela Pacella3
1Department of Neuroscience, Reproductive Sciences, and Dentistry, "Federico II" University, Naples, Italy.
每日低剂量阿司匹林显著降低了患2型糖尿病 (T2D) 的风险,特别是当与COVID-19相关时. 这一发现表明阿司匹林.
科学领域:
- 内部医学 内部医学
- 流行病学 流行病学
- 药理学 药理学是指药理学的学科.
背景情况:
- COVID-19与新发型2型糖尿病 (T2D) 的风险增加有关.
- 炎症在T2D的发展中起着关键作用,特别是在病毒感染的背景下.
研究的目的:
- 调查每日低剂量阿司匹林对T2D发展的潜在保护作用.
- 评估阿司匹林的使用是否会改变与COVID-19相关的T2D风险.
主要方法:
- 从2018-2022年对20万名成年人的纵向队列的分析.
- 倾向性得分匹配以比较阿司匹林使用者与非使用者之间的T2D发病率.
- 考克斯回归和卡普兰-梅尔分析来评估降低风险.
主要成果:
- 与非使用者相比,阿司匹林使用者的T2D发病率明显较低.
- 考克斯回归显示,阿司匹林组的T2D风险降低了52%.
- 阿司匹林的保护作用在COVID-19前和期间都很明显,在COVID-19期间更强烈的关联.
结论:
- 每日低剂量阿司匹林显著降低了新发型T2D的风险,特别是COVID-19相关的T2D.
- 研究结果强调了炎症在COVID-19相关的T2D病原发生中的作用.
- 低剂量阿司匹林可能是一个有价值的干预措施,以预防2型糖尿病的风险人群.
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