基因组分析揭示了中国成年人年龄,肠道微生物群和骨质损失之间的联系
Yufeng Li1, Zhun Shi2,3, Xiuying Zhang4
1Department of Endocrinology, Beijing Friendship Hospital Pinggu Campus, Capital Medical University, Beijing, China. doctorlyf@126.com.
npj metabolic health and disease..
|July 3, 2025
概括
肠道微生物影响骨健康. 特定的Lachnospiraceae物种及其代谢途径与更高的骨矿物密度 (BMD) 有关,而某些肠肠类型会影响与年龄相关的骨质损失.
科学领域:
- 微生物组研究的研究.
- 骨的新陈代谢 骨的新陈代谢
- 老龄化研究研究.
背景情况:
- 越来越多的证据将肠道微生物群与骨健康联系起来.
- 老龄化,肠道微生物群和骨质疏松症之间的相互作用尚未完全理解.
研究的目的:
- 调查中国成年人肠道微生物组成与骨矿物质密度 (BMD) 之间的关联.
- 探索衰老和肠道微生物群对骨质疏松症发展的影响.
主要方法:
- 量化计算断层扫描 (QCT) 用于腰部BMD测量.
- 在684名中国成年人的肠道微生物群中进行了枪支元基因组测序.
- 统计分析,以确定微生物物种,途径和骨硬化之间的相关性,控制混因素.
主要成果:
- 在BMD和Lachnospiraceae物种之间发现了积极的关联 (例如,Lachnospira eligens,Blautia wexlerae,Roseburia hominis).
- L-氨酸生物合成和丁酸盐生产途径与BMD正相关,独立于年龄,饮食和生活方式.
- 与独立队列中验证的Prevotella enterotype相比,Bacteroides enterotype的个体显示出与年龄相关的BMD下降幅度更大,与Prevotella enterotype相比.
结论:
- 特定的肠道微生物特征,包括Lachnospiraceae的丰富性和某些代谢途径,与骨健康有关.
- 肠道微生物群的组成,特别是肠型,与衰老相互作用,影响骨矿物质密度.
- 这些发现表明,基于微生物群的干预措施对于骨质疏松症的预防和治疗有潜力.
更多相关视频
06:59Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
Published on: September 8, 2023
2.7K
09:37A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation
Published on: March 15, 2018
13.3K
相关概念视频
01:29Bone Disorders
4.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.0K
01:40Bone Remodeling
38.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.5K
01:25Role of Vitamins in Maintaining Bone Health
3.7K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.7K
01:09Changes in the Appendicular Skeleton with Age
2.3K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
2.3K