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在SNARE拆卸时,需要Sec18/NSF侧载荷

Yousuf A Khan1,2,3,4, K Ian White5,6,7,8,9, Richard A Pfuetzner5,6,7,8,9

  • 1Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA, USA. yousuf@stanford.edu.

Nature structural & molecular biology
|July 3, 2025
PubMed
概括

在细胞膜融合后,Sec18/NSF (N-乙烯胺胺敏感因子) 和Sec17/α-SNAP将SNARE蛋白束分解. 新的冷-EM结构显示Sec18/NSF线索通过其ATPase环通过SNAREs,使侧载和卸载成为可能.

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