在怀孕的患者中,Akkermansia的效果引起了高血压
Changfang Yao1, Yanjun Yang1, Min Qiu1
1Department of Obstetrics, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, Jiangsu Province, China.
BMC microbiology
|July 3, 2025
概括
妊娠引起的高血压 (PIH) 与改变的肠道细菌有关,特别是较低的Akkermansia和较高的Firmicutes. 这些肠道微生物组的变化与PIH患者炎症标志物增加有关.
科学领域:
- 微生物学 微生物学
- 产科 产科 产科 产科 产科
- 免疫学 免疫学 免疫学
背景情况:
- 怀孕早期的肠道失调与怀孕引起的高血压 (PIH) 有关.
- 肠道微生物群的特定变化及其在PIH中的机制在很大程度上是未知的.
- 了解这些联系对于管理PIH至关重要.
研究的目的:
- 为了研究PIH的孕妇的肠道微生物群组成.
- 探索PIH中肠道失调和炎症标志物之间的关系.
- 为了确定PIH的潜在微生物生物标志物.
主要方法:
- 使用了一个嵌套的病例控制研究设计.
- 16S rRNA测序分析了19名PIH患者和20名健康孕妇的肠道微生物群.
- 通过ELISA测量了炎症性细胞因子 (IL-1β,IL-6,TNF-α,IL-8,IL-10,IL-18) 和酶-1的血水平.
主要成果:
- 与对照组相比,PIH患者的微生物α多样性显著降低,Verrucomicrobia的丰度减少,Firmicutes的丰度更高.
- 肠道微生物组健康指数 (GMHI) 在PIH组明显较低.
- 在PIH中,阿克尔曼西亚的丰富程度下降,IL-18和卡斯巴酶-1的血水平升高,阿克尔曼西亚与PIH中的这些炎症标志物有积极的相关性.
结论:
- 肠道功能失调,以减少阿克尔曼西亚和改变类丰度为特征,与PIH有关.
- 在PIH中存在增加的促炎细胞因子 (IL-18,caspase-1),可能与特定的肠道细菌 (如Akkermansia) 有关.
- 这些发现突显了肠道微生物组在PIH病原发生中的作用,并表明了潜在的治疗点.
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