相关实验视频
Updated: Sep 17, 2025

09:39
A Microfluidic Model of Biomimetically Breathing Pulmonary Acinar Airways
Published on: May 9, 2016
8.1K
刚性支气管镜中的喷气通风动态:来自模拟实验模型的见解
Mingyuan Yang1, Zhuomin Deng2, Xin He1
1Department of Anesthesiology, Emergency General Hospital, Beijing, 100028, China.
BMC anesthesiology
|July 3, 2025
概括
正常频喷气通风 (NFJV) 提供更大的潮体积,而高频喷气通风 (HFJV) 可能会导致二氧化碳的保留. 叠加高频喷气通风 (SHFJV) 对复杂的气道显示出前景,突出了对个性化设置的需求.
科学领域:
- 麻醉学 麻醉学
- 呼吸系统生理学 呼吸系统生理学
- 医疗工程 医学工程
背景情况:
- 在刚性支气管镜检查期间,喷气通风对于气道管理至关重要.
- 由于流动动力学数据有限,目前的手术内管理依赖于SpO2和血液气体分析.
- 为了优化患者护理,需要对喷气通风参数的客观数据.
研究的目的:
- 研究不同喷气通风模式 (NFJV,HFJV,SHFJV),驱动压力和频率对空气流动学的影响.
- 在模拟的气道模型中分析气道峰值压力 (Pike),正极呼气压 (PEEP) 和潮体积 (Vt).
- 为优化刚性支气管镜术中的通风策略提供数据.
主要方法:
- 使用3D打印的刚性支气管镜和人工气道模型.
- 集成喷气式呼吸机,空气流分析仪和试验肺用于数据采集.
- 在不同的通风模式,驱动压力和频率下测量Peak,PEEP和Vt.
主要成果:
- 增加频率通常会降低Ppeak和Vt,同时增加PEEP.
- 在所有模式中,更高的驾驶压力增加了峰值,PEEP和Vt.
- 在较低的频率下,NFJV提供了更高的Vt;在高频率下,HFJV显示了更低的Vt;在压力调整下,SHFJV显示了动态Vt范围.
结论:
- NFJV提供了更大的潮体积,而HFJV可能会导致二氧化碳的保留.
- 通过结合两种模式的优势,SHFJV为复杂的气道管理提供了潜在的解决方案.
- 基于气道机理的通风参数的个性化选择对于安全有效的患者护理至关重要.
相关概念视频
Factors Affecting Pulmonary Ventilation
1.6K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.6K
Mechanical Ventilation II: Invasive Ventilation
262
Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
262
Assessment of Ventilation I: Respiratory Rate
1.3K
Assessment of Ventilation
A Ventilation assessment is critical for monitoring a patient's health status. Respiration, one of the most accessible vital signs, provides insights into the function of numerous body systems and can indicate serious health issues, such as brainstem injuries from head trauma.
Critical Guidelines for Assessing Ventilation:
A Ventilation assessment is critical for monitoring a patient's health status. Respiration, one of the most accessible vital signs, provides insights into the function of numerous body systems and can indicate serious health issues, such as brainstem injuries from head trauma.
Critical Guidelines for Assessing Ventilation:
1.3K
Pulmonary Ventilation: Inhalation
4.8K
Pulmonary ventilation is a vital process that ensures the exchange of oxygen and carbon dioxide in the lungs. It refers to the movement of air into and out of the lungs, enabling the body to obtain oxygen and remove waste carbon dioxide. In this article, we will explore the intricacies of pulmonary ventilation, including its underlying principles, mechanisms, and the interplay of pressures within the respiratory system.
Boyle's law becomes particularly pertinent when examining respiratory...
Boyle's law becomes particularly pertinent when examining respiratory...
4.8K
Endoscopic Studies I: Bronchoscopy and Thoracoscopy
276
Endoscopy is a non-surgical medical technique used to examine a person's internal organs and vessels. This lesson will focus on two types of endoscopic studies: bronchoscopy and thoracoscopy.
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
276

