主观认知衰退中的认知储备与担忧:DMN-VN连接支持结构脆弱性下的情节性记忆
Lanli Jiang1,2, Shaokun Zhao1,2, Ting Li1,2
1State Key Laboratory of Cognitive Neuroscience and Learning, Faculty of Psychology, Beijing Normal University, Beijing, 100875, China.
BMC geriatrics
|July 3, 2025
概括
患有主观认知衰退和焦虑症 (SCD+) 的个体表现出大脑结构的改变和增强的网络连接,这可能表明早期的认知储备. 这可能会支持尽管海马的脆弱性,尽管插曲性记忆,建议基于任务的fMRI可以检测这些变化.
科学领域:
- 神经科学是一个神经科学.
- 认知衰退研究 研究认知衰退
- 阿尔茨海默病病理生理病理学
背景情况:
- 对主观认知衰退 (SCD) 的担忧增加了阿尔茨海默氏症 (AD) 和认知衰退的风险.
- 患有SCD和焦虑症 (SCD+) 个体的明确记忆和神经成像概况尚未得到充分理解.
- 识别这些个人资料对于早期检测和干预策略至关重要.
研究的目的:
- 为了确定与SCD和焦虑 (SCD+) 的老年人中与情节性记忆相关的脑成像特征.
- 研究大脑结构-功能-情节性记忆路径中的潜在补偿机制.
- 为了区分SCD+和SCD组之间的神经成像和记忆配置文件.
主要方法:
- 结构性MRI和基于任务的功能性MRI (fMRI) 分别对来自BABRI队列的418名和153名患者进行.
- 参与者被分为轻度认知障碍 (MCI),SCD+,SCD和正常控制 (NC) 组.
- 使用大脑结构-功能-情节性记忆路径模型来分析补偿机制.
主要成果:
- SCD+和SCD组在情节性记忆任务上表现相似.
- 与SCD相比,SCD+组在后海马体和副海马体皮质中表现出改变的灰质缩模式.
- 在默认模式网络 (DMN) 和其他网络中,SCD+组的功能连接 (FC) 比SCD显著更强.
结论:
- 较强的DMN-VN连接可能代表早期的认知储备,尽管结构脆弱,但在SCD+中支持情节性记忆.
- 随着阿尔茨海默病的进展,这些适应机制可能会变得脆弱.
- 基于任务的fMRI显示为一种有希望的敏感工具,可以在临床衰退之前检测这些早期过程.
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