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手术后短期术后并发症和术后肠道功能之间的关联 对于希尔施普朗格病的手术
Zhengxing Jiang1, Jinping Hou1, Xiaohong Die1
1Department of General & Neonatal Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, 20 Jinyu Street, Yubei District, Chongqing, China.
手术后并发症和长段疾病是导致赫施普朗格病 (HSCR) 患者肠功能不佳的关键风险因素. 早期的手术可以改善肠道功能结果.
科学领域:
- 儿科手术 儿科手术
- 胃肠病学 胃肠病学
- 临床结果研究研究
背景情况:
- 赫施普隆病 (HSCR) 是一种先天性疾病,影响大肠,导致肠道阻塞.
- 手术后的肠功能是HSCR患者长期生活质量的关键决定因素.
- 识别肠道功能不良的危险因素对于改善患者管理至关重要.
研究的目的:
- 研究HSCR患者的短期术后并发症和肠功能之间的关联.
- 确定在HSCR治疗后影响术后肠功能的独立风险因素.
- 探索手术时间对肠功能结果的影响.
主要方法:
- 对367名HSCR患者的医疗记录进行了回顾性审查.
- 使用肠功能评分对肠功能进行分类 (BFS>17正常,BFS ≤17异常).
- 使用Clavien-Mendadi (CM) 分类来分析并发症;用于风险因素识别的单变量和多变量逻辑回归.
主要成果:
- 长段疾病 (OR=3.255),配方养 (OR=3.081),轻度并发症 (OR=9.560) 和严重并发症 (OR=17.127) 是肠道功能低下的重要危险因素.
- 1至3岁之间的手术与肠道功能不良的发病率降低有关 (OR=0.357).
- 手术后的并发症与肠道功能受损有很强的相关性.
结论:
- 手术后的并发症,长段疾病和配方食是HSCR肠道功能不佳的独立预测因素.
- 1至3年间的手术干预可能有助于预防肠道功能不良.
- 建议进行更大规模的多中心研究来验证这些发现.
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