轻度认知障碍的老年人握力,6分钟步行距离和工作记忆之间的关系:fNIRS研究
Peng Wang1, Yanran Si2, Zhidong Cai3
1Shanghai University of Sport, Shanghai, 200438, China.
BMC geriatrics
|July 3, 2025
概括
患有轻度认知障碍 (MCI) 的老年人表现出工作记忆的减少,特别是在一次性任务中. 更好的握力和走路耐力与改善的工作记忆和特定的前额叶皮层活动相关.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 认知科学 认知科学
背景情况:
- 轻度认知障碍 (MCI) 影响老年人,影响工作记忆等认知功能.
- 了解MCI工作记忆缺陷的神经相关因素和物理预测因素对于有针对性的干预措施至关重要.
研究的目的:
- 调查MCI的老年人握力,6分钟步行距离 (6MWD) 和工作记忆之间的关系.
- 在工作记忆任务中使用功能近红外光谱 (fNIRS) 探索神经机制.
主要方法:
- 招募了72名60岁以上的MCI患者,通过蒙特利尔认知评估 (MoCA) 进行评估.
- 测量了抓地力和6MWD的强度.
- 使用fNIRS来监测N-back任务 (0-back,1-back,2-back) 中的前额叶皮层血流.
主要成果:
- 摩卡分数与1回表现的相关性最强.
- 在高性能1背组中观察到左背侧前额叶皮层 (dlPFC),右 dlPFC和右腹侧前额叶皮层 (vlPFC) 的更高激活.
- 握力和6MWD与跨越认知负载的工作记忆性能有显著的相关性,特别是1-back.
- 握力和6MWD显示与特定的前额叶皮层激活通道具有正相关性.
结论:
- 患有MCI的认知能力下降与工作记忆缺陷有关,而一回复性表现是一个敏感的指标.
- 前额叶皮层激活模式与MCI中的工作记忆性能有关.
- 像握力和6MWD这样的物理措施与MCI老年人的更好的工作记忆和神经激活有关.
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