怀孕早期的甘油三和血压:一种结合预测子宫前的预测因素
Ying Zhu1, Hui Wang2, Si-Yi Wei1
1Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, 200011, China.
在怀孕早期,血压升高和高甘油三水平显著增加了孕前的风险. 将1期高血压与高甘油三化合物相结合,具有显著的风险,突出了临床关注的关键子组.
科学领域:
- 产科和妇科 产科和妇科
- 怀孕期间的心血管健康
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 血压升高和甘油三 (TG) 水平与不良妊娠结果有关.
- 虽然第二阶段的高血压是已知的孕前预测因素,但较低血压类别的影响需要进一步调查.
- 识别怀孕早期的风险因素对于管理子宫前至关重要.
研究的目的:
- 评估妊娠早期血压和TG水平对孕前风险的综合影响.
- 确定需要更密切的临床监测的高风险孕妇子组.
- 为了澄清不同高血压阶段与TG水平的预后意义.
主要方法:
- 对78,016例单子婴儿的回顾性队列研究 (上海IPMCH, 2014-2019).
- 参与者根据怀孕早期的血压 (正常血压,高血压,第一阶段,第二阶段高血压) 和TG水平 (高于/低于90百分位) 进行分类.
- 用于分析关联的通用添加和逻辑回归模型.
主要成果:
- 孕前发生在2.83%的参与者 (2,204例).
- 第1阶段和第2阶段的高血压显著增加了孕前的风险 (AOR分别为3.40和6.96).
- 高TG水平在所有血压类别中放大了孕前风险,在第一阶段高血压和高TG (OR1.50) 中观察到协同风险.
结论:
- 血压升高和高TG水平的结合,特别是1或2阶段高血压,大大增加了孕前的风险.
- 与高TG水平同时发生的第一阶段高血压代表了一个显著的危险因素,与单独的第二阶段高血压相比.
- 早期识别这种综合风险概况对于有针对性的临床干预至关重要.
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