在老年人中,多维脆弱性和动力衰竭与跌倒风险的关联
Maryam Ghorbanzadeh1, Afsaneh Bakhtiari2, Karimollah Hajian-Tilaki3
1Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
BMC geriatrics
|July 3, 2025
概括
肌力衰弱 (与年龄相关的肌肉衰弱) 和虚弱显著增加老年人的跌倒风险. 它们的联合存在显示了剂量依赖的效果,突出了需要综合评估来管理高风险个体的需要.
科学领域:
- 老年学是一门学科.
- 老年病的医生 老年病的医生
- 公共卫生 公共卫生
背景情况:
- 动力衰竭和虚弱是老年人功能衰退和死亡率的既定预测因素.
- 动脉变现象,脆弱领域和跌倒风险之间的相互作用仍然不够理解.
- 这项研究解决了关于动脉和脆弱性对跌倒风险的综合影响的知识差距.
研究的目的:
- 研究老年人中跌倒风险,dynapenia表型和脆弱的不同领域之间的关系.
- 确定动脉和虚弱与降落风险增加的独立和联合关联.
- 探索动脉动脉,脆弱领域和跌倒风险之间的剂量反应关系.
主要方法:
- 400名65岁以上的门诊患者的横截面研究.
- 跌倒风险是使用伯格平衡量级评估的.
- 通过手握动力测量确定动力的表型;使用TFI在身体,心理和社会领域评估脆弱性.
- 应用单变量和多变量回归分析来检查关联.
主要成果:
- 动力衰弱和多维虚弱独立地与较高的跌倒风险相关 (分别为OR=2.75和OR=2.56).
- 动力衰弱和虚弱的同时出现显着增加了跌倒风险 (OR=20.45).
- 身体和社会脆弱的领域,与动力症结合,显示了明显的剂量取决于跌倒风险的增加.
结论:
- 动力衰竭和虚弱,特别是涉及身体和社会领域,独立而协同地增加了老年人的跌倒风险.
- 动力衰弱和虚弱的联合存在对跌倒风险具有剂量依赖的影响.
- 综合评估对于识别和管理跌倒风险最高的老年人至关重要.
相关概念视频
Drug Dosing: Geriatric Patients
365
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
365
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
351
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
351
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
329
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
329
Pharmacodynamics in Geriatric Patients: Effects of Age
333
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
333
Development of Human Microbiota
44
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
44


