母亲红细胞叶酸和维生素B代谢与怀孕结果:一项回顾性研究
Limin Peng1,2, Yan Gao1, Chengkun Yuan1
1Department of Obstetrics, The First Affiliated Hospital , Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, China.
BMC pregnancy and childbirth
|July 3, 2025
概括
维生素B的新陈代谢显著影响怀孕的结果. 叶酸,维生素B2和B6的较高水平与正常怀孕有关,而甲基马龙酸和同类素的升高水平则表明不良结果.
科学领域:
- 产科和妇科 产科和妇科
- 营养科学 营养科学
- 生物化学 生物化学
背景情况:
- 在怀孕期间,维生素B对孕产妇和胎儿的健康至关重要.
- 维生素B代谢干扰对怀孕结果的具体影响需要进一步研究.
研究的目的:
- 调查维生素B代谢与不良妊娠结果 (APO) 之间的关联.
- 开发APO风险评估的预测模型.
主要方法:
- 对1086名孕妇进行了回顾性分析.
- 评估的维生素B标记物:叶酸 (5MTHF),维生素B2 (VB2),维生素B6 (VB6),甲基马龙酸 (MMA) 和同氨酸 (HCY).
- 利用LASSO和后勤回归用于模型开发和验证.
主要成果:
- 增加的MMA和HCY水平与增加的APO风险相关 (P<0.05).
- 较高的血-5MTHF,RBC-5MTHF,RBC-VB2和RBC-VB6与正常结果有关.
- 预测模型在训练集中实现了0.85的AUC,在外部验证中达到0.807.
结论:
- 维生素B代谢的改变与怀孕的结果有显著的联系.
- 开发的预测模型为临床风险评估提供了有价值的工具.
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