相关实验视频
Updated: Sep 17, 2025

03:52
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
520
肥胖症,体力活动及其对美国成年人生物衰老的综合影响
Che Wang1,2, Rujie Zheng3, Wenjuan Song3
1School of Medicine, Nankai University, Tianjin, China.
BMC public health
|July 3, 2025
概括
肥胖症 (SO) 显著增加了美国成年人的生物衰老风险,特别是与身体不活动相结合时. 解决SO对于促进健康老龄化和延长健康寿命至关重要.
科学领域:
- 老年学是一门学科.
- 公共卫生 公共卫生
- 代谢健康 代谢健康
背景情况:
- 生物衰老与时间衰老不同,受生活方式和生理因素的影响.
- 麻症和麻性肥胖症 (SO) 是肌肉损失和多余脂肪的特征,可能会影响健康轨迹.
- 身体活动 (PA) 是已知的健康和衰老过程的调节者.
研究的目的:
- 在美国成年人中,调查萨科佩尼亚,萨科佩尼性肥胖 (SO) 和体力活动 (PA) 状态与表型年龄加速 (PhenoAgeAccel) 的独立和联合关联.
- 量化SO和PA缺乏对加速生物衰老的潜在影响.
主要方法:
- 来自国家健康和营养检查调查 (NHANES) 2005-2010年和2015-2018年的9661名美国成年人的分析.
- 现型年龄加速 (PhenoAgeAccel) 计算为从PhenoAge的余量回归到时间学年龄.
- 使用FNIH定义确定了肉症和SO;进行了加权多变量逻辑回归和人口归因分数 (PAF) 分析.
主要成果:
- 单独 Sarcopenia 与 PhenoAgeAccel 并没有显著相关.
- 标本性肥胖 (SO) 与增加的PhenoAgeAccel (OR 2.68) 有显著的关联.
- SO和体力活动 (PA) 缺乏的组合显示出PhenoAgeAccel (OR 3.87) 的最高风险,SO导致风险增加29.3%,PA缺乏为18.5%.
结论:
- 肥胖症 (SO) 是加速生物衰老的重要危险因素,特别是在年轻和中年人中.
- SO和体力活动 (PA) 缺乏的协同效应显著增加了加速衰老的风险.
- 针对SO的干预措施对于促进健康老龄化和改善健康寿命至关重要.
更多相关视频
13:35Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
Published on: March 21, 2021
10.8K
12:59Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
Published on: July 5, 2017
12.7K
相关概念视频
The Effect of Aging on Tissues
2.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.6K
Bone Disorders
4.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.0K
Changes in the Appendicular Skeleton with Age
2.3K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
2.3K
Aging
193
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
193
Obesity
624
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
624