一项基于监测的病学研究,研究了中国2007-2020年2500万例新生儿的代
Yuyang Gao1,2, Wenli Xu1,2, Wenyan Li1
1National Center for Birth Defects Monitoring, West China Second University Hospital, Sichuan University, No.17 Section 3 Renminnanlu, Chengdu, Sichuan, 610041, China.
BMC pregnancy and childbirth
|July 3, 2025
概括
在中国,衰 (RA) 的患病率正在增加,单边 (URA) 和双边 (BRA) 形式具有不同的风险因素和结果. 早期诊断和咨询对受影响的家庭至关重要.
科学领域:
- 生殖医学 生殖医学
- 儿科 儿科 儿科
- 公共卫生 公共卫生
背景情况:
- 衰老 (RA) 是一种罕见的先天性缺陷,临床严重程度可变.
- 单边代 (URA) 更常见,可能导致长期并发症.
- 双边生病 (BRA) 通常是致命的,这突显了中国需要流行病学数据的需要.
研究的目的:
- 对中国的RA进行全面的流行病学分析.
- 确定RA,URA和BRA的流行率,时间趋势和相关因素.
- 调查RA的婴儿的妊娠结果和同时发生的异常.
主要方法:
- 利用中国出生缺陷监测网络 (2007-2020) 的数据.
- 根据人口和地理因素分层计算的流行率.
- 采用波桑回归来确定与URA和BRA患病率相关的因素,并分析妊娠结果.
主要成果:
- 确定了5906例RA病例 (2.28/10,000例出生),RA,URA和BRA的流行趋势正在增加.
- 与URA相比,BRA显示出明显更糟糕的妊娠结果 (早产,低出生体重,新生儿死亡,TOPFA).
- 在城市地区,东部/中部地区观察到较高的RA患病率,对URA和BRA有特定的母亲年龄和婴儿性别关联.
结论:
- 这项研究提供了中国RA的第一个广泛的流行病学评估.
- 随着RA患病率的增加和URA和BRA之间的不同结果,需要改进产前诊断.
- 对受RA影响的家庭进行适当的遗传咨询至关重要.
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