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如何估计基于凝的软囊外的泄漏现象?
Chungang Zhang1,2,3, Chao Xie4, Zitong Qiao4
1College of Pharmacy, Liaoning University of Traditional Chinese Medicine, No. 77, Life One Road, DD Port, Dalian, 116600, China. zhangchungangpharm@outlook.com.
BMC chemistry
|July 3, 2025
概括
这项研究开发了一种方法来预测质软囊在储存期间的泄漏情况. 基于吸收水分和机械性能的模型估计了各种条件下的保质期.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 物理化学 物理化学
背景情况:
- 基于凝的软囊被广泛用于药物输送.
- 了解和预测囊泄漏对于确保产品稳定性和保质期至关重要.
- 目前评估泄漏稳定性的方法有限.
研究的目的:
- 开发一种可靠的方法来估计在储存过程中基于凝的软囊外的泄漏稳定性.
- 调查泄漏的潜在机制,重点关注吸收水分和机械性能.
- 建立预测模型,以估计囊在各种环境条件下的保质期.
主要方法:
- 福利埃变换红外光谱 (FTIR) 和扫描电子显微镜 (SEM) 用于分析囊的组成和形态.
- 进行了光动力学和宏观机械分析,以评估水分吸收和机械性能随时间推移.
- 应用了阿雷尼乌斯方程和一般化的艾灵模型来开发泄漏的预测模型.
主要成果:
- 囊泄漏主要归因于凝的胀,而不是化学降解,随着温度和湿度的增加.
- 在质量变化率 (吸收水分) 和囊的机械性能之间建立了直接的相关性.
- 开发的Arrhenius和一般化的Eyring模型准确地预测了在各种存储条件下泄漏的发生.
结论:
- 该研究提供了一种可靠的方法来估计凝软囊的泄漏稳定性.
- 这些发现强调了吸收水分和机械完整性在确定囊保质期方面的重要性.
- 已建立的模型为预测产品的保质期和优化质软囊储存条件提供了有价值的工具.
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