胰岛素抵抗作为肥胖和牙周炎风险之间的媒介
Shuai Jiang1, Chen Liang2, Jing Jing3
1Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, 266001, China.
BMC oral health
|July 3, 2025
概括
通过HOMA-IR测量的胰岛素耐药性显著介导了肥胖 (BMI,WC) 和牙周炎之间的联系. 管理代谢健康是减少与肥胖相关的牙周病风险的关键.
科学领域:
- 口腔健康研究研究 口腔健康研究
- 代谢性疾病研究研究
- 公共卫生 公共卫生
背景情况:
- 肥胖是牙周炎的已知危险因素,牙周炎是一种具有全身影响的慢性炎症状况.
- 通过HOMA-IR量化的胰岛素耐药性是研究这种关系的比糖尿病更精确的调解器.
- 了解这些联系对于全身和口腔健康管理至关重要.
研究的目的:
- 研究肥胖,胰岛素抵抗 (HOMA-IR) 和牙周炎之间的关联.
- 专门研究HOMA-IR在肥胖和牙周炎之间关系中的调解作用.
主要方法:
- 分析了来自8473名参与者的NHANES数据 (2009-2012).
- 通过BMI和腰围 (WC) 来评估肥胖.
- 使用HOMA-IR测量胰岛素耐药性和牙周炎通过临床附着损失和探针深度.
- 应用物流回归,限制立方线和调解分析.
主要成果:
- 无论是BMI还是WC都显示出与牙周炎风险增加的显著关联 (P <0.05).
- HOMA-IR与牙周炎风险有积极联系 (P < 0.01).
- 在BMI与牙周炎的关联中,HOMA-IR为63.44%,在WC与牙周炎的关联中为36.77%.
结论:
- 胰岛素耐药性 (HOMA-IR) 显著调解肥胖和牙周炎之间的关系.
- 早期代谢调节对于减轻与肥胖相关的牙周风险至关重要.
- 研究结果提供了对全身和口腔健康相互作用的机制性见解.
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