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嵌合式抗原受体工程细胞免疫疗法的当前挑战和新兴机遇

Yong Liu1,2, Yifei Duan3, Zefan Du3,4

  • 1Pediatric Hematology Laboratory, Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518107, Guangdong, China. liuy995@mail2.sysu.edu.cn.

Experimental hematology & oncology
|July 3, 2025
PubMed
概括

化学抗原受体 (CAR) 免疫疗法,包括CAR-T,CAR-NK和CAR-M细胞,显示出癌症治疗的前景. 本综述考察了它们的疗效,挑战和未来的临床潜力.

关键词:
在CAR-M中,它是最重要的.卡尔-NK 是一个卡尔-NK.在CART-T中,使用CART-T.临床应用 临床应用免疫治疗是一种免疫疗法.

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Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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