热:一种炎症反应,对卷烟暴露的毒性影响
Astari Pranindya-Sari1,2,3,4, Reviono1,5, Agus Dwi Susanto6
1Doctoral Program of Medical Science, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia.
概括
香烟烟雾会引发炎症性细胞死亡的灭,导致肺部和全身疾病. 针对这一途径为吸烟相关疾病提供了新的治疗策略.
科学领域:
- 细胞生物学 细胞生物学
- 免疫学 免疫学 免疫学
- 毒理学 毒理学 毒理学
背景情况:
- 香烟烟雾 (CS) 诱导细胞损伤和慢性炎症,导致各种疾病.
- 虽然先前已经认识到了细胞亡,但现在已经确定了依赖于酶-1 (CASP-1) 的炎症性细胞死亡,即亡,作为CS暴露的关键病理机制.
- Pyroptosis 涉及气皮素 D (GSDMD) 裂变,膜孔形成,以及 IL-1β 和 IL-18 等炎症性细胞因子的释放.
研究的目的:
- 审查和综合现有证据,探讨烟雾灭在香烟烟雾引起的疾病中的作用.
- 探索将CS暴露与热和其下游效应联系在一起的机制.
- 确定潜在的治疗目标,以减轻CS诱导的病理.
主要方法:
- 在PubMed,Scopus,Web of Science和Google Scholar中对2014年至2024年间发表的文章进行了全面的文献搜索.
- 搜索术语包括"火","香烟烟雾","炎症体","caspase-1"和"gasdermin D".
- 来自知名的Scopus索引期刊的英语文章,重点关注 pyroptotic 机制,疾病进展和治疗干预措施.
主要成果:
- 暴露于CS激活了炎症体,导致CASP-1激活和GSDMD介导的热.
- 这种 pyroptotic 途径加剧慢性肺部疾病 (例如,COPD,肺气) 并导致肺外疾病 (例如,动脉样硬化,肝功能障碍,神经炎症).
- CASP-1的抑制剂,炎症组分和天然化合物在抑制热和减少CS诱导的组织损伤方面表现有前途.
结论:
- 烟是香烟烟雾引起的疾病中关键的炎症途径.
- 针对炎症体信号传递和 pyroptotic 中介体是一个有前途的治疗策略.
- 进一步了解烧死机制可能会导致吸烟相关病理的新干预措施.
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