肠道感觉神经元作为神经免疫微生物相互作用的调节者:从分子机制到IBD/IBS的精密疗法
Ning Sun1, Li-Shuang Cao1, Wan-Yu Xia1
1Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, Sichuan, China.
肠道感觉神经元是肠道中的关键生物传感器,影响着平衡. 针对这些神经元,神经通路和肠道微生物,为炎症性肠病 (IBD) 和易怒肠综合征 (IBS) 提供了一种新的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道感觉神经元作为生物传感器,集成机械,化学和微生物信号来维持肠道平衡.
- 这些神经元在炎症性肠病 (IBD) 和刺激性肠综合征 (IBS) 中发挥作用,但它们的确切机制尚不清楚.
- 肠道神经系统中的内在初级附带神经元 (IPAN) 与背部根 (DRG) 和阴道 (NG/JG) 神经元相比,具有独特的分子配置.
研究的目的:
- 审查关于肠道感觉神经元在肠道疾病中的作用的最新发现.
- 探索IBD和IBS的新型综合治疗框架.
- 讨论这个框架对个性化医疗的翻译潜力.
主要方法:
- 关于肠道感官神经元和肠道疾病的当前研究的综合文献综述.
- 分析不同感官神经元亚型 (IPAN,DRG,NG/JG) 的独特特征.
- 探索三重协同治疗策略:分子调制,神经调节和微生物群重编程.
主要成果:
- 肠道感觉神经元对于通过神经化学信号的双向上皮质-免疫通信至关重要.
- 涉及这些神经元的动态神经调节网络与肠道疾病病理生理学有关.
- 拟议的治疗框架整合了分子,系统和生态方法.
结论:
- 肠道感觉神经元对于肠道平衡至关重要,并与IBD/IBS病原发生有关.
- 针对神经递质,神经刺激和肠道微生物群的综合治疗策略具有前景.
- 这种方法可能会导致IBD和IBS的个性化临床干预.
更多相关视频
10:37Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
06:57Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
Published on: September 18, 2016
相关概念视频
Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Physiology of Enteric Nervous System and Gut Health
Neural Regulation
Enteric Nervous System: Regulation of GI Motor Activity
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
Nerve Supply of the GI Tract
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of...
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
