在4-18岁的健康中国儿童肺功能测试的参考方程
Jinhong Wu1, Hao Zhang2, Yufen Wu1
1Department of Internal Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 400127, China.
Respiratory research
|July 3, 2025
概括
为健康的中国儿童开发了新的螺旋计参考方程,为诊断呼吸系统疾病提供了更高的准确性. 这些方程解释了当代的增长和区域多样性,优于现有的全球和中国模型.
科学领域:
- 肺部医学 肺部医学
- 儿科呼吸系统健康 儿科呼吸系统健康
- 生物统计学 生物统计学
背景情况:
- 精确的螺旋计参考方程对于诊断和管理儿科呼吸道疾病至关重要.
- 现有的全球方程 (例如,GLI) 对亚洲人口的数据有限.
- 对健康的中国儿童而言,需要特定的螺旋计参考方程.
研究的目的:
- 为4-18岁的健康中国儿童开发和验证新的螺旋计参考方程.
- 将这些新方程的性能与现有的高加索和中国儿科参考方程进行比较.
- 为评估中国儿科患者肺功能提供准确的工具.
主要方法:
- 在中国24个地区对8929名健康的汉族儿童 (年龄在4-18岁) 进行了横截面研究.
- 收集了螺旋测量,物理测量 (身高,体重) 和人口统计数据.
- 为了开发新的预测方程,使用了结合年龄,身高和体重的多个线性回归模型.
主要成果:
- 年龄,体重和身高是肺功能的重要预测因素 (p < 0.001).
- 新开发的性别特异性方程在内部验证中显示出高准确性 (平均z分数: -0.004至 -0.069).
- 与新的中国方程相比,现有的扎普莱塔尔方程和GLI方程显示了肺功能参数的高/低估.
结论:
- 为健康的中国儿童量身定制的新螺旋计参考方程已经开发出来.
- 这些方程反映了中国当前的增长模式和地区差异.
- 新方程式为中国儿科呼吸系统评估提供了有价值,准确的临床工具.
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